surprised no one is trying metformin seeing that it modulates DNMT, HDAC, AR mRNA etc
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Yep I’m on 250 mg now. It should be known metformin Can lower testosterone, so that’s why I’m on such a low dose. I took it cause I was exhausted after meals and had high ish fasting glucose.
It’s giving me slightly better energy! Haven’t been exhausted after a meal in a while, too.
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yeah the OP paper says it is a mixed HDAC inhibitor/agonist that must be why it fucks testosterone/igf receptors
curcumin(injectable) or hydralazine might be a better choice with a HDAC inhibitor like valproate
they are just as good as metformin for longevity it seems
and what they all have in common?? DNA methyltransferase inhibition 
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David sinclair an anti aging doctor uses it because it activates sirtuins pathways just as exercise and fasting does.