"Methylcobalamin is well transporter to nerve cells organelles, and promotes nucleic acid and protein synthesis in animal studies : Methylcobalamin was shown to be better transporter to nerve cell organelles than cyanocobalamin. It has also been shown in experiments with cells from the brain origin and spinal nerve calls to be involved in the synthesis of thymidine from deoxyuridine, promotion of deposited folate utilization and metabolism of nucleic acid. Also, methylcobalamin plays role in nucleic acid and protein synthesis more than adenosylcobalamin does. Methylcobalamin promotes axonal transport and axonal regeneration : Methylcobalamin normalizes axonal skeletal protein transport in sciatic nerve cells from rat models with streptozotocin-induced diabetes mellitus. It exhibits neuropathologically and electrophysiologically inhibitory effects on nerve degeneration in neuropathies induced by drugs, such as adriamycin, acrylamide, and vincristine, models of axonal degeneration in mice and neuropathies in rats with spontaneous diabetes mellitus. Methylcobalamin promotes myelination (phospholipids synthesis) : Methylcobalamin promotes the synthesis of lecithin, the main constituent of medullary sheath lipids, and increases myelination of neurons in tissue culture more than adenosylcobalsmin does.
From:
biocondiabetology.com/resour … bil-pi.pdf
“Methylcobalamin promotes myelinisation. Methylcobalamin donates methyl group to homocysteine to form methionine. Methionine transfers methyl group for the formation of lecithine, which is helpful in the formation of myelin sheath.It also promotes axonal regeration.”
From:
saffermion.com/Booket%20for%20Hicobal.pdf
“methylcobalamin at concentrations above 100 nM promotes neurite outgrowth and neuronal survival and that these effects are mediated by the methylation cycle, a metabolic pathway involving methylation reactions. We also demonstrate that methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle. In a rat sciatic nerve injury model, continuous administration of high doses of methylcobalamin improves nerve regeneration and functional recovery.”
From:
sciencedirect.com/science?_o … c474319150
