Merck - The evil of Big Pharma in America

Many of you have probably already seen this but I am gonna throw it right on the forum for everyone’s easy access.

Info on Merck from their wikipedia page:

"In 1999, the U.S. Food and Drug Administration (FDA) approved Vioxx (known generically as rofecoxib), a Merck product for treating arthritis. Vioxx was stronger than existing medications, while easier on the stomach than established anti-inflammatory drugs such as naproxen. Vioxx became one of the most prescribed drugs in history. According to internal e-mail traffic released at a later lawsuit, Merck had a list of doctors critical of Vioxx to be “neutralised” or “discredited.” “We may need to seek them out and destroy them where they live,” wrote an employee. Also alleged were intimidation of researchers and impingement upon academic freedom.

On September 23, 2004, Merck received information about results from a clinical trial it was conducting that included findings of increased risk of heart attacks among Vioxx users who had been using the medication for over eighteen months.[14] On September 28, 2004, Merck notified the FDA that it was voluntarily withdrawing Vioxx from the market, and it publicly announced the withdrawal on September 30. The FDA has since recommended that Vioxx be put back on the market, but with a more prominent warning regarding cardiovascular risks on its label.

On November 5, 2004 the medical journal The Lancet published the results of its analysis of the available studies. It concluded that “the unacceptable cardiovascular risks of Vioxx (rofecoxib) were evident as early as 2000…”[15] The journal’s editors criticized Merck for having kept the drug on the market as long as it did before withdrawing it, and also criticized the FDA for its failure of regulatory oversight.

About 50,000 people have sued Merck claiming that they or their family members have suffered medical problems such as heart attacks or strokes after taking Vioxx.[16] In 2005, Merck was found liable in the first case that went to trial and the plaintiff was awarded $253.4 million in damages; however, the judgement was subsequently reduced to $20 million and then, upon appeal, the verdict was reversed in 2008.[16] In November 2007, Merck proposed to pay $4.85 billion to settle most of the pending Vioxx lawsuits.[17][18] The settlement will require that claimants provide medical proof of having suffered a heart attack or a stroke and show they received at least 30 Vioxx pills. This proposed settlement is generally viewed by industry analysts and investors as a victory for Merck, considering that original estimates of Merck’s liability reached as high as $50 billion. As of mid-2008, plaintiffs have prevailed in only three of the twenty cases that have reached juries, all with relatively small awards.[16]

On May 20, 2008, Merck was found liable for using deceptive marketing tactics to promote Vioxx and 30 states will split the $58 million settlement. The amount is the largest multi-state settlement against a pharmaceutical company.[19] All its new television pain-advertisements must be vetted by the Food and Drug Administration and changed or delayed upon request until 2018."

I think this just clearly shows you essentially the evil intents of this company which values its income statements more than its consumers health. Looking to discredit and alienate doctors who question their medications, even internal talk of silencing them.

What might be even more sad is the pathetic settlement of $4.85 billion when compared with the damage the drug did to people (and the amount of people) versus the monetary value of this company. It is a display of the American government failing to hold those responsible for crimes up to the justice they deserve. The FDA failed them and the courts failed them. This is what we are up against, a company whose total assets are valued in excess of $105 billion. A company who is so engrained into the American economy and health system that our own government agencys and courts who are ment to police such coorperations for their misdeeds were held in trepidition from preforming actions against them.

The FDA will drag their feet with this, and may never in fact do anything until scientists prove it on their own. The courts must have determined that the amount of money really due to the people who suffered was to great for Merck to bear and decided bank-rupting them would not be for the greater good. I believe a company with a such a track record as this deserves not only to be completely and utterly bankrupted and all their assets liquidated and paid out to those suffering, but I would more so lean toward what the Chinese do with coorperate leaders in their country who commit great misdeeds… you can figure that out on your own.

All we can wish for is justice to prevail for once.

It’s up to us

There are very few things in this world that make me feel honest hatred, but when I think of what this company has done to us, I genuinely feel it boiling inside me. And the longer the FDA goes without doing anything about it, the more I feel it towards them.

We are the passengers on the hijacked 9/11 planes. We’re going down, but the question is, how? Are we gonna live as long as we can till the hijackers crash the plane and let others die with us, or are we gonna storm the cockpit and take fate into our own hands?

Look at my seond sig. This was a statement from Dr. Kauffman of Merck to the FDA Propecia Review Panel. This was said by a doctor to a room full of endocrinologists, and no one called him out on it. It’d be laughable if it weren’t so sad.

Yep, that’s pretty sick.

No we are not.

Unless you are metaphorically having a go at the U.S government.

Don’t forget Singulair! They’re facing lawsuits because of that drug as well. It’s an allergy/asthma medication that has been reported to fuck up the brain in some users, and the worst part is that it’s prescribed to children! I just discovered something interesting; Propecia was marketed in 1997, Singulair in 1998 and Vioxx in 1999. I wonder how the company was doing financially before these drugs were marketed, and who was responsible for the projects. I refuse to believe that they didn’t see any warning signs during the development of these drugs, but I do believe that the serious adverse effects weren’t that common, and that they chose to look the other way - because they knew that it would be difficult to prove that these drugs were responsible for any damage.

P. Roy Vagelos

This is the cocksucker responsible for this horrible drug, depending on how much blame you place on the researcher who developed it that is. Of course he is a multi-millionaire many times over.

en.wikipedia.org/wiki/P._Roy_Vagelos

Is it a coincidence that he received the Bower Award for business leadership in 1999?

Vagelos developed the drug to treat BPH, for which it is considered a very effective treatment. I don’t know if you can blame him for its use for alopecia. Most likely what happened is that the business team saw another way to make millions from the same drug, and so marketed it for alopecia. It takes millions of dollars and years to develop a new drug. So for merck, this was a huge success. I would blame the business sociopaths who make the major decisions. I don’t know if you read that post by someone (can’t remember) which listed a website where people were posting about how relieved they felt not to work for Merck anymore. Their consciences couldn’t take it.

Umm he is still to blame, regardless of what he made it to treat, the side effects are there for everyone who takes it for whatever reason they are taking it. He went to a conferance about birth defects and DHT inhibition was brought up. He thought to himself “hmm I can make a drug that does the samething and make a mint off of it.” There are lots of older guys who took it for BPH and have the same sides as us, they are just less aware of it because of their age (their docs blame it on age) and probably because they are much older and not as internet savy.

But if you feel like defending an asshole who helped put us all in this situation because he didn’t properly investigate his “wonder drug” than thats your perogative.

EDIT: Don’t get me wrong thou, I blame their business people just as much… as well as their current spineless CEO who defended a drug that was killing people and that landed him his CEO position.

Didnt we have a thread around here titled “Beware of Greeks bearing gifts”?

[youtube]http://www.youtube.com/watch?v=-fRpgGkgA-c[/youtube]

Theres really no evidence for this. There are no ‘lots of guys’ - persistent sides from Finasteride use are very rare, we are in less than 1 in 1000 territory.

The mistake Merck has made is not changing their warning labels and not making changes prominent enough as soon as they became aware that there where reports of a link between Finasteride and ED. Thats all. It was a business decision which very aptly highlights the problems when capitalism and healthcare collide.

naturalnews.com/035519_Ron_Paul_FDA_Big_Pharma.html

Who are you guys in the US voting for in the election?

The Merck executive that really deserves to be vilified is Raymond Gilmartin. He succeeded Roy Vagelos to become President and CEO in 1994 and “led” the company during the period Vioxx and Propecia gained approval by the FDA.

My understanding is that Merck was actually one of the most respected and ethical corporations for a long time until Raymond Gilmartin took the reins as he was not a scientist/doctor and came from a marketing/business background. As far as I know, Ray Vagelos is a respectable individual and has actually sharply criticized Gilmartin and the direction which he took Merck after the two switched places. Gilmartin was humiliated by the Vioxx scandal and was kind of forced to resign before his early retirement which was only a year or two away. He is now a professor at the Harvard School of Business and the man who served as head legal counsel during Vioxx is now the chief executive at Merck.

Gilmartin writes a blog for Harvard and he often reads and sometimes responds to his posts. People have torn him apart in some of his recent posts so I think he gave up the blogging. Feel free to write whatever you would like to him - I find it to be a bit therapeutic but the man is largely in a state of denial for his business and moral failings. It is nice to see other people despise him as much as we do.

blogs.hbr.org/hbsfaculty/2011/09/ceos-need-a-new-set-of-beliefs.html

Believe me, I am infuriated as the rest of you, but I just wanted to present what I believe to be a more fair perspective.

This is very true. Had the warning label adequately reflected the true risks, I certainly would have never taken the drug as I never cared that much about hairloss. Even after I initially developed side effects, I was improperly advised by my doctors since they were just going off what was in the prescribing information. Had they known about the possibility of irreversible side effects it is undeniable that I would be in a better place today.

Yes I believe you’re right. After watching the vid, Vagelos claims he “institutionalized” the thinking that led to Merck’s subsequent discoveries (57-58 min). Vagelos bemoans the fact that the person he groomed to succeed him left the company and Gilmartin came in soon after (1hr10).

I’m sorry didn’t know you conducted a survey to quantify the number of PFS sufferers. I do not have evidence, but neither do you to make such a statement. It has been said by many many people on this very site that there are likely many other people who have been effected but are unaware of the cause of their side effects or are not coming forward at all. So before you come here and discredit me for making a statement with no evidence, bring some evidence of your own. The fact is nobody knows for sure how many have been effected.

These individuals also contributed to the drug’s development:


Dr. Burton G. Christensen

acsmedchem.org/christensen.html


Irreversible inhibition of human 5.alpha.-reductase

Merck Patent:
google.com/patents?id=x_MXAAAAEBAJ&printsec=abstract&zoom=4&dq=patent+finasteride+slow+binding#v=onepage&q=patent%20finasteride%20slow%20binding&f=false

Inventors:
Herb G. Bull
Georgianna S. Harris