I have PSSD and I suspect in my individual case Allopregnanolone is high, therefore I want to lower it. Before trying to reverse PSSD.
My idea was to use a 5ARI to lower conversion from progesterone to 5a DHP and consequently Allopregnanolone.
I came across GHK-Cu, copper ions are 5AR1 inhibitors. GHK-Cu passes the BBB so it should also work in the brain. The combo I wanted to run was GHK-Cu + Zinc, which should theoretically lower Allopregnanolone.
If you have any inputs or suggestions, if there is a better method, I would be thankful. The other thing I had in mind was using a GAMSA which directly antagonizes the PAM effect of Allopregnanolone on GABA but those aren’t really affordable. Fin/Dutasteride seem too dangerous.