Low COMT activity?


#1

Hello,

I work at a lab that does genetic testing and I was able to do my own for free. One result that caught my attention is that I tested for severely reduced COMT activity. The normal genotype is G/G and I tested for A/A. From doing some reading it seems COMT has a role in methylation of neurotransmitters such as dopamine to clear them from a certain area of the brain. Anyone else who’s done the 23and me get a result like this? Could finasteride have messed with this system in the brain that COMT regulates?


#2

Which Comt? I have Comt v158m (AG), Comt h62h (CT) Comt P199P (GG)


#3

V158M. Your heterozygous results indicate that you have reduced COMT activity but not as reduced as mine. That’s the only alleles for that gene that I had tested so I couldn’t tell you about the other ones.


#4

Yeah - I think the 23andMe project needs to be coupled with the survey. I think we are dealing with mutiple things and comparing my strictly neurological symtoms to someone with strictly joint pain, may not yield any correlation. I do believe however, if you compare my data with the few folks who have neurological issues, there could be a correlation. I believe our population/sample is too broad to yield any results. I hope the admins are planning on performing more than one analysis of the data.


#5

Also for those who want to comment, the methylation report (free) from geneticgenie.org will ingest your data and give the results above.


#6

I’m also homogeneous in the MTRR and the estrogen toxicity gene


#7

I’m waiting on my 23 and me kit to get my full raw data and I’ll update this thread when I get my results. But from what I tested at work, that was the only thing that stuck out


#8

Should also mention that the genetic report gives me a list of prescription medications and tells me how I’d respond to them based on my genes. It has finasteride and dutasteride in the green category which means safe to use with standard precautions, LOL.


#9

I wonder if there is a way to tell what they are looking for


#10

I can ask tomorrow but I’m sure it’s probably just based on how well your liver metabolizes the drug or something. It’s not for pfs or anything


#11

Another data point for this discussion:

In addition to the reproductive and mental problems of PFS I have neurological symptoms including persistent paresthesia. I also have potential autonomic nerve issues including digestive problems, night sweating, heart palpitations, and dizziness.

No doctor has been able to diagnose the cause and no doctor I speak to about PFS knows about it or seems interested in considering it.

I took Propecia for 3 years in my 30s and 2 rounds of Accutane in my 20s.

My methylation profile:
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO A R297R rs6323 G -/-
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 GG -/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 AA -/-
MTRR H595Y rs10380 CC -/-
MTRR K350A rs162036 AA -/-
MTRR R415T not found
MTRR A664A rs1802059 GG -/-
BHMT-02 rs567754 CT +/-
BHMT-04 not found
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-02 not found
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 AG +/-
CBS A360A rs1801181 GG -/-
CBS N212N not found
SHMT1 C1420T not found