Have SSRI guys seen this?
Im not sure how far your going to get trying to nail down changes in gene expression.
Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus
Analysis of the samples resulted in 258 genes that were significantly upregulated and 218 genes that were significantly downregulated by fluoxetine treatment
Rapid short term changes,
SSRI treatment during adulthood alters gene expression levels of hypothalamic hormones, neurotrophic factors, inflammatory factors and components of non-serotonergic neurotransmitter systems.34, 35, 36 Especially the inflammatory factors might have a central role in mediating the effects of SSRIs, because downregulation of proinflammatory cytokines can inhibit HPA axis function (facilitating stress reduction), enhance 5-HT and dopamine synthesis and inhibit 5-HT and dopamine reuptake