LH Pulsatility in Subjects with 5a-Reductase Deficiency and Decreased DHT Production

Science Other Studies
#1

Since Finasteride’s method of action is to alter a normal male hormonal profile moreso to match that of a pseudohermaphrodite (ie, ncbi.nlm.nih.gov/sites/entre … ds=1689740), and since Fin useage is associated with decreased DHT and increased Testosterone/Estrogen levels, the following may offer an explanation as to why.

Also note the average control hormone ranges and values of men aged 19-35:

Total T: 24.2 nmol/L
T/E2 ratio: 211

LH Pulsatility in Subjects with 5a-Reductase Deficiency and Decreased Dihydrotestosterone Production

FULL PDF: jcem.endojournals.org/cgi/reprint/78/4/916.pdf

ABSTRACT:

The pattern of LH pulsatility in male pseudohermaphrodites with inherited 5 alpha-reductase-2 deficiency (5 alpha RD) and decreased levels of plasma dihydrotestosterone was compared to that in normal males.

Analysis of 10-min plasma LH sampling during either a 10- or 24- h period demonstrated that the subjects with 5 alpha RD had 1) a mean plasma LH level, mean LH pulse amplitude, and mean plasma LH nadir that were approximately twice normal; and 2) a mean LH pulse frequency similar to that in normal males, whether described as pulses per h or pulses per study period.

An increased plasma LH response to GnRH administration was also noted. The findings suggest that a deficiency of DHT results in decreased negative feedback at the level of the hypothalamus and/or pituitary, resulting in an increase in mean plasma LH, LH pulse amplitude, and LH responsiveness to GnRH.

In response to increased LH, mean plasma testosterone (T), free T, and plasma estradiol (E2) are increased. The pulse amplitude is increased despite elevated plasma T and E2 levels; this underscores the importance of DHT in pulse amplitude regulation.

LH pulse frequency is not decreased despite elevated plasma T and E2, raising the possibility that DHT deficiency increased pulse frequency that was normalized by increased T and/or E2.

In conclusion, studies of LH pulsatility in subjects with 5 alpha RD suggest a role for DHT in the modulation of LH.

Selected bits:

… " Thus, from these studies it can be postulated that the decreased DHT levels in subjects with inherited 5aRD result in the loss of negative feedback at the level of hypothalamus and/or pituitary. The increased pulse amplitude, despite elevated plasma T and E2 levels (9, 14), highlights the importance of DHT in pulse amplitude regulation."

#2

what do you hope to accomplish by posting these vague studies? do u ever plan on seeing professional help to address your problem? just curious. it seems like u do a lot of posting of several studies hoping someone will make something of them. and also by posting the random studies you seem to have this whole forum thinking you’re full of knowledge when you haven’t been able to do anything of the sort to help yourself.

i think it’s dangerous to lead a forum when you don’t even take any initiative of addressing your issues other than posting random studies that don’t mean squat. I mean seriously, who has any labs with DHT being too low? the activity mentioned below highlights why there are side effects listed on the packet.

what does the study suggest?..that there are risks to Fin. i think you all knew that when you took it the first time…and second time (after quitting from sides the first time)

Jack

#3

Most studies indicate that gonadotropins are unaltered by finasteride.

It seems plausible that decreased DHT (less negative feedback), combined with increased E (more negative feedback), is responsible for this null effect.

Why does decreasing DHT increase E, though? I imagine this is due to the fact that blocking conversion to DHT means more build-up of T, which in turn translates to an increase in E. If this is the mechanism, it seems to make sense that finasteride should really have no significant effect on the HPTA axis.

The ill effects of the drug must be mediated elsewhere, probably acting on some latently congenital/environmentally novel abnormality.

#4

What do I hope to accomplish? Just doing research, nobody’s forcing you to read it.

Yes, I have been trying to locally with various doctors and endos but seems I will likely need to fly to the US at some point.

Sure, the day a medical professional comes along and can comment on all this will be great. Until then, we can only hypothesize amongst ourselves.

You are mistaken, I don’t claim to be full of knowledge, never have and never will. I’m just a layman, a guy in his late 20s affected by this drug, looking for answers and evidence of its effects and mechanisms of action to present to medical professionals – hence my research into studies.

I don’t claim to “lead” this forum. I volunteered to set it up, I administer it, and I present my own opinions on things just like everyone else. Besides criticizing those on here like me who have put in valuable time and effort, what have you done? Do you know how many people are thankful this site even exists? LOTS.

Nobody’s forcing you to stick around, your problems aren’t even Finasteride related as you’ve said yourself. Granted you do offer the occasional reality check but other than that, you tend to enjoy stirring up crap and picking fights.

And the studies might not mean squat to you, but I find them interesting, as may others.

Maybe DHT isn’t the reason people are having issues after stopping the drug. That’s one of the problems, nobody knows what happens and why the issues continue for some.

Yawn, yea and plenty of us were told side effects resolve after discontinuing and that only 2% of men get them by Merck. Total BS.

Anyway, if you have nothing constructive to add to posts, don’t bother. As I said before, your issues aren’t even Fin related so not sure why you’re even here.

#5

I never said you claim to be knowlegdable…it just comes off as if you are with SO MANY studies.

I accept your whole post and respect your points. As for me picking fights…I do tend to do it. I don’t really care to fight but just enjoy putting a reality check out there.

I do frequent the board here as some of the posts are just entertainment and put me into a reality check that Finasteride isn’t responsible for anything mentioned on this site.

Take care
Jack

#6

Just coincidences, huh?

#7

Depression really does cover a lot of symptoms so it’s understandable that they all relate some how. Also, when someone says they have something so vague it’s easy for someone else to agree so they can sleep easier at night that they share something in common along with Fin so it must be caused by Fin.

Jack

#8

Could be, but I’d say that the depression is secondary due to your body being fucked up. But I’m sure the depression doesn’t help with healing and symptoms. I really doubt that depression causes new veins on your pecker or painful eyes.