Part 3 - Letrozole Clinical Trial
On June the 3rd of this year, I commenced an eight week trial of Letrozole (Aromatase Inhibitior).
Weeks 1 - 4 of the trial were a bit rough. My fatigue got worse, really bad, like the bad old days before taking Thyroid meds.
I got strange sides initially, but all managable - Like, Dry mouth, sore lips, fatigue(which already mentioned), total loss of Libido, very vivid dreams, bad headaches. However, during this time, I got my first nocturnal erection, raging one at that, it actually woke me out of my sleep. It had been almost five years since I had one! so I was prepared to continue the trial, even with the sides.
Weeks 5 - 8 of the trial were easier. The fatigue started to wear off, my mood became really positive, like I was falling in love with life again, hard to explain, but, somehow, everything felt better. Even stressful days were no problem. Morning and Nocturnal erections were now frequent, as in every day or every second day.
I started on 1.25mg of Letrozole for the first 2 weeks than upto 2.5mg after this for the remaining 6 weeks.
During this time, my Endo, ran blood tests every second week, although he wouldnāt give me a printout of the numbers, on meeting him at the end of the eight week trial, my body had responded so well to the treatment, that he decided to extend it another eight weeks, this time however, reducing the Letrozole back from 2.5mg every day to 1.25mg every day.
Weeks 8 - 16 - Life just continued to get better, my strength and energy came back, by the end of the 16 weeks, I was back reading complicated litrature again, something I hadnāt been able to do since taking Proscar. On meeting with my endo at the end of this extension of the trial, he was amazed by how well I was responding. He decided to continue me on the clincial trial for another eight weeks, this time, reducing my T3 Medication from 20mcg everyday to 10mcg everyday with a view to coming off it completely. Upto this point, It had been impossible for me to stop taking T3 meds, as the minute I did,I would start to feel really shitty very quickly. The only negative during this part of the trial, was that I started to get bone pain (Like a sharp electric shock in your bones and joints) it was painfull, I can assure you.
Weeks 17 - 25 - Once again, my Endo continued the trial, however, this time, I had to reduce the Letrozole down from 1.25mg everyday to 1.25mg every second day. In addition, I also had to reduce my T3 meds down from 10mcg everyday to 10mcg every second day, then after 4 weeks to every third day and then stop T3 Med altogether. Which I have done.
By tapering back on the Letrozole to every second day, has helped with the bone pain.
On my last meeting with my Endo on the 19th of December 2014, I have to continue on Letrozole 1.25mg every second day till the end of January, then retest bloods. Then taper Letrozole to 1.25mg every third day for eight weeks, and then retest bloods, and meet him at the beginging of April.
Short on Positives and Negatives to Letrozole for Me.
Positivesā¦
Nocturnal, Morning and Spontenious Erections are back
Fatigue completely gone
Mental clarity, focus back
Love of Life and Wife back
Strength and Energy - Good
Sexual preformance - Good
Negativesā¦
Total loss of Libido (Desire to have sex)
Although bone pain has subsided, still get it occasioinally
Muscle strain (back, neck and shoulders) lasts for days at a time
I wonāt be on this site much from here on in, so I really hope this helps people out there.
