I am writing this to warn you guys on something you will not find over the web.
I have been suffering strong and constant pelvic pain for months now. I suspect it’s pudendal nerve related pain as it’s sharp and fluctuates through the perineum, testicles and penis, and it gets way stronger every time i try to exercise. I have taken different analgesics and NSAIDs to no avail. Then I decided to give a try to a low dose gabapentin as it’s shown first line therapy for pudendal neuralgia. Next day ED was worsened. Penile sensitivity which i already had decreased was worsened as well. However it lasted just a day and i got back to the baseline the day after. Pain stayed strong and constant though so i couldn’t function normally.
After searching on a treatment i found SSRI, SNRI, and Lamotrigine shown as 2nd line therapy for pudendal neuralgia. Without having a single thought of using any of first two, I decided to go with Lamotrigine. The initial lowest dose is 25 mg so i decided to start with even lower one. 12.5 mg first day. After my second dose of 12.5 mg i woke up with completely dead penis. Today is 3th day since discontinuation and seems it’s getting worse as I am experiencing an extreme lack of sensitivity. No matter how strong i squeeze my penis, I feel absolutely nothing. Pain is much less but the significant worsening I got is not fun at all.
lamotrigine is shown as safe in terms of sexual sides drug. It’s hard to find cases reporting such effects. Stay away from Lamotrigine!