I was worried I was getting Kennedys or some other androgen receptor disease at the beginning with my muscle loss and shrinkage, neuro seemed to rule it out. I thought you’d seen a neuro?
How did he rule this out? A nerve conduction test?
I don’t think so, he made me walk about and did that thing where they hit your knee for a reflex. He probably did a couple of other things I’ve forgotten about. He was cool and believed my story but said it would ‘flush out of my system’ then referred me on to an endo. No EMG testing or whatever it was that mew got.
I did see a Neuro but who knows what she is thinking
soemthing else of note. i remember that JN had gotten much better with HGH which increases IGF-1
Its your theory, so prove it right or wrong or youre wasting everyones time
haha ordering right now buddy its open in the other tab right now - by the way im hoping for the love of GOD that this ISNT what we have this would be aweful. a disease that makes your AR not work and the more testosterone you give it the worse it gets
thank you for doing that wontgiveup
no worries! whats another hundred bucks at this point
mda.org/publications/Quest/e … /sbma.html
Mice with an SBMA-like disease benefited from extra IGF1 genes in their muscle fibers
Note: “LIKE-disease” even if we dont have this disease… this wasnt the exact thing either but IGF1 helped
Nice one bud, 
Got tested for this this morning via an emg and nerve conduction test - which let me tell you is not pleasant (they stick needles in your muscles and move them around) and it was 100 percent normal.
Have you had any muscle loss/twitches?
Guys, do you know dutasteride is Kennedy Disease patients miracle drug?
Maybe we suffer something similar, in that andorgens/ dht are harmful for us ever since they returned when dropping finasteride
Post links to info regarding this to elaborate further please.
kennedysdisease.blogspot.com/2011/07/dutasteride-update-five-months.html
kennedysdisease.blogspot.com/2011/09/dutasteride-and-asc-j9-updates.html
ncbi.nlm.nih.gov/pubmed/21216197
Kennedy’s disease is completely different to PFS obviously, but i think it’s interesting because it is something to do with the androgen receptor and DHT is not good for these guys. Considering so many of us ‘crashed’ when DHT probably came flooding back, you never know, maybe it is harmful for us too? i am not trying to put forward a serious theory here, simply writing down some thoughts. I am most interested in there use of dutasteride.
I think Blase is onto something when he talks about DHT being pro inflammatory in some cases. The ‘crash’ event makes me think we had/ are having a bad reaction to DHT since we stopped suppressing it by 70% using finasteride.
“Spinal and bulbar muscular atrophy (SBMA) or Kennedy’s disease is a slowly progressive,
X-linked motor neuron disease for which there is currently no treatment. It is caused by a
mutation in the androgen receptor that results in a polyglutamine repeat expansion. Recent
animal studies have demonstrated that decreasing endogenous androgen levels leads to
functional improvement and increased survival. Studies have also shown that high levels of
5 alpha-reductase, the enzyme that converts testosterone to the more potent
dihydrotestosterone (DHT), are present in the ventral spinal cord, while low levels of this
enzyme are found within skeletal muscle. Thus, by selectively decreasing levels of DHT with
dutasteride, a 5 alpha-reductase inhibitor, it is hypothesized that there will be a
selective protection of motor neurons, without the adverse effects of reducing the anabolic
effects of androgen on muscle.”
I don’t know how long you guys want to ignore the fact that 5 AR inhibitors have in cases helped PFS. I certainly am not.
Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial
ncbi.nlm.nih.gov/pubmed/21216197
Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy
ncbi.nlm.nih.gov/pubmed/19259967
Followed by…
Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial (2010)
ncbi.nlm.nih.gov/pubmed/20691641
Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives.
ncbi.nlm.nih.gov/pubmed/15133611
There are some interesting similarities; ‘ligand-dependent toxicity’. But anti-androgens arent used for this condition and its not a miracle drug for them - even for the person in the blog.
Can I ask bluecloud87 aka Joe-91/Uk20/sanfran55/BaldyLocks to stop lying and trying to encourage continued use of Finasteide.
Anti androgens ARE used for this condition. Check the blog and you will see that a number of men have had very positive experiences from using Dutasteride. The term miracle drug was used rather loosely but it’s no surprise to see you taking it literally. I am not encouraging the use of 5 AR inhibitors; i am simply saying that they have helped some post finasteride sufferers. Which is a fact.
Crawl back into your little hole Oscar. Your what, 30 or something like that? and yet you are persistently bitter with people in the same dire situation as yourself. And revealing details and bald jokes? aren’t you balding and wasting away yourself? seriously, it’s about time you grew up mate.
If you think so why don’t you continue to take finasteride? Why aren’t you on it now?
No one is trying to deny the short honeymoon period you felt while retaking the drug. However other people feel directly worse when taking 5AR inhibitors. I think we’re all more concerned about the more serious, long-term sides after discontinuing use.