Kan's story - One of the most severe stories of PFS

One for me Ritalin is saved my libido. it really has attributes that reverse ssri induced and finasteride induced sexual dysfunction.
If i cease to use and quit methylphenidate my libido goes down dick became unresponsive.
I think Ritalin fuels your anxiety thats why you became much much worse.
And with your case i am sure that pfs hits very hard if there is an underlying mood disorder.
Also new generation anti-psychotic medications antagonize serotonin 2A receptors which helps with sexual function but old generation anti dopaminergic ones kills libido increases prolactin and destroyers your sexual health. What Ritalin does is the opposite of this.

I’ve had periods of anger, nothing good came from them.
Also our inner voice can also be negative and drive us to making poor choices. Think of the opposite thought to the negative one, even write them both down helps the mind see another solution/idea.

I am not 100% sure that anxiety itself can increase fibrosis and atheroesclerosis, but it could be, who knows.

Ritalin has anti-androgenic properties.


“The results of this study confirmed that MPH can negatively affect serum testosterone concentration and fertility rate of the male mice”

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Hello, do decide with one paper on animals

https://www.liebertpub.com/doi/abs/10.1089/cap.2008.0161?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=cap

Though it affects testosterone but it is nothing like Finasteride and most of the cause is weight loss and increased metabolism.

But same time it directly stimulates reward system on sexual behavior.

Yes, it’s not similar to finasteride, but drugs that didn’t cause me problems before finasteride, now they can cause me several problems.

If the problem is in the androgen receptor, then it doesn’t matter if ritalin increases libido with dopamine, because if it lowers androgens, then when ritalin is stopped androgens come back again and can negatively affect the androgen receptors (that in people with PFS are already “damaged” if the AR theory is right).

I don’t know, I don’t totally discard that the whole PFS has a neurological origin, but some things happening in penile tissues and other physical symptoms are very difficult to explain.

Of course but I do not think it is a receptor issue we already have increased receptors, it might be altered e2/dht ratio or epigenetic changes on 5a-reductase enzyme activity. We mostly retain male characteristics like, facial hair, body hair with this kind of sexual dysfunction, we should have seen like eunuchs. Damage caused by lack of androgens are almost totally reversible but if there is a neurological damage it will be hard, if it will heal it would take a very long time.

These days I am having trouble when driving. Everytime I drive more than 15-20 minutes I end up with pain in the muscles of the arms and lower legs that lasts some days. The pain in the legs is similar as the pain I get when walking too much.

One of the things that is new to me these past months is that I get very vivid nightmares almost every night. I tend to wake up very tired.

Btw, when I say “these past months” I mean exactly since the day I last crashed.

Sorry to hear that Kan.

I hope that resolves for you very soon. If the nightmares are a PFS symptom, who would have thought they were even possibly a side effect!

I hope you get a good day very soon

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Stay strong mate. Dealing with ups and downs here.
I am struggling with adjusting a diet since food is a major trigger on sleep and its quality and overall tiredness…

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If one day I have to take the car and attend different meetings, then I’ll get 3-4 days of quite horrible muscle pain and fatigue. Right now my arms and legs ache so much…

In the past I had some hopes of qualifying for disability if things got bad (as bad as they are now) because a doctor diagnosed me with chronic fatigue syndrome. But since a nice psychiatrist diagnosed me with delusional disorder some months ago, things will be more complicated if I try to get disability benefits.

My relationship with my parents is not good since they put me in the psychiatric hospital and crashed, but this means that I have to force myself to work at least to get the minimum necessary money, as asking them for help would imply a new humiliation or nasty comments from them.

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Hey @kan > PM
Typically the case where a chat function would be useful :D.
These posts totally justifies a quick access to the OP!

@kan you’re a soldier bro

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I know you are a grown up person and i don’t want to say anything about your familys attitude. But thats sucks man, they probably think you are making this condition up in your mind right? Jesus christ. You should seriously talk to them and show this forum or something. Wish you the best. Btw do you smoke medical marijuana? A nice indica strain may help with you with those pains…

Last Wednesday I did a blood test.I asked to measure CK in the blood test too, despite the skepticism of the doctor, who thinks measuring CK is not reliable. Next Wednesday I’ll have the results.

I have also an appointment tomorrow to check if I have pudendal neuralgia. I’ll have an EMG and a neurography at the area of the sphincter muscles.

Regarding denervation, I guess in case of muscle atrophy in the sphincter area, the EMG would also reveal this if this was the case? Anyone has done some research on this?

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Creatine kinase was within the ranges. I don’t know if this is good news, I am starting to think that part of our problems may be psychogenic. There is no doubt about my body changes, but can this be caused by my mind?
I don’t know, these last months I have changed my mind many times on what I think PFS may be. I wish I could go back to before my last crash, I was happy not caring too much about PFS.

Others with muscle loss have reported the same:

I did the test three days after having my last orgasm, which is when I feel that I have some trouble with muscles (from the day of the orgasm until 2-3 days later). Maybe in the future I’ll do the test again closer to the moment of the orgasm.

I don’t know. The only test I have that proves damage is a penile doppler that shows artherosclerosis, fibrosis, etc. And this started at the moment my penis went hard-flaccid, a syndrome which now I have read is mainly caused by stress.

Also, most people in this forum haven’t got any test showing any kind of damage, apart from some annecdotical test like my penile doppler (some people on this forum have done this doppler and came back normal for them). I understand that if the problem is in the AR, then it is normal that we have problems even with our Testosterone levels being normal. But shouldn’t some tests show the damage that this could be causing in some areas of the body?

For example, many people have had problems like eye pain, extreme eye floaters, vision problems, etc. But when they go to the ophtalmologist the answer is always the same: your eyes are fine. I have read that eye problems that cannot be proven are one of the first signs of a psychogenic illness. Also I feel like we are trying to make strange maneuvers to connect some of the strange symptoms some people have with the main theory.

I don’t know, I am having a week in which I feel a little bit lost, and even though I am playing a little bit the devil’s advocate in this last post, I must admit that for the first time in 8 years I am starting to have some doubts about some things.

Anyway, I have postponed my perineal EMG until next Tuesday.

Edit: I forgot to update that my horrible brand new restless leg syndrome that started after taking one pill of olanzapine has gotten worse and nights are being “fun” before falling asleep. Many studies talk about this syndrome being caused or aggravated by antipsychotics (such as olanzapine) and other drugs that block dopamine receptors.

Kan, after the EMG evaluation maybe consider trying Magnesium L Threonate (MagTein formula). I do have experiences with RLS and this compound is best among any Mg that there are and also has other advantages like getting Mg through BBB that You will simply wouldnt get from other Mgs. Start low and slow and build dose to desired effect and give it some time. I wish You luck and to get better soon

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The results of the perineal emg found partial denervation (I dont know if I am doing the translation well, but I think it’s this in english).

The doctor who did the test says the causes can be multiple, but need to talk to the doctor who ordered the test.

I am having nerve pains and paresthesias in different areas since I did the electromyogram. It also happened when I had x-rays three years ago.

Hi @Kan,

It’s inappropriate to suggest others’ symptoms are psychosomatic. I don’t know why you appear to be gaslighting yourself but I have seen you are now already heading for another rabbit hole in another topic:

You didn’t even know you had this until a test I specifically recommended to you in this thread. The chain of events above is as follows.

Then you appeared to suggest the problems of others were psychosomatic.

You are not familiar with the medical findings of others and the test you pursued per my suggestion revealed moderate denervation.

I have no idea what you meant by this and I don’t know what these strange manoeuvres are or who “we” are in this context. A cursory look at this forum would probably suggest to an outside observer the “main theory” is to do with an imaginary bacteria or metals. There is no “main theory” in the minds of patients, at this point there’s probably more “theories” than registered users, and barely any take account of the real situation or clinical picture in the first place. If you mean the view of the administrators, we haven’t shared our recent efforts with forum members so I don’t see how anyone is connecting anything to it. I suppose that EMG was a very lucky guess, considering I don’t see this being discussed in patient groupings. Or, maybe it wasn’t.

I suggest instead of worrying about theories, or trying to form another based on this result, you focus on looking after yourself. A few members have said they were upset at you suggesting their symptoms were psychogenic considering the extent of their symptoms, especially when you consider yourself severely affected. You were quite upset above when a user suggested your own problems were caused by your own lifestyle, so please consider how others might feel reading you say that considering the devastating effect this has had on many users who are profoundly affected. @Tzinkman wrote of this here.

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