Is this the scientific proof we have been waiting for?

Therapeutic Efforts Pharmaceutical
#1

Many now realize that use of Finasteride can result in premature Andropause which can be devastating to say the least.

For me, I was only on Propecia for two minths before I started seeing emotionally devastating side effects. I quit the drug immediately thinking the drug company had told the truth that such side effects would reverse after discontinued use and like many here they just progressed.

I began research into Andropause but was never satisfied with the T/HCG protocol as I wanted to go more to the root of the matter. If T causes negative feedback resulting in infertility and almost undetectable LH why would I want to take it? Also, why take HCG as it only mimicks LH and other than experience there is really no way to test the optimal regime/level.

Thus, I began on the path as how to eliminate the negative feedback of T or how to increase LH as naturally as possible so I could increase my T naturally and then if needed begin TRT without any negative feedback in regards to LH and FSH.

This research led me to the following study:

endo.endojournals.org/cgi/conten … 41/11/3940

A truly amazing study about a drug named Baclofen and how it reverses the negative feedback of T. Although this study is on the intravenous baclofen, you may be interested in knowing that it is classified as a safe drug and is available in pill form here in the USA.

Now you may remember a poster here that told of his remarkable story of how he came back from the hell caused by Finasteride with a drug known as GHB. Many here gave him no credit. However, as it turns out this scientific study may indeed support his case. Why? Because GHB and baclofen share many of the same properties in that they both are considered a GABA B agonist and they both are Muscle relaxers. Coincidence? I think not?

dr-bob.org/babble/20020402/msgs/101866.html

Now if this indeed turns out to be true, this will revolutionize anti-aging medicine and may indeed bring many here back from the pits of hell.

Can you imagine if you have Andropause what it would be like to take Baclofen or other such as GHB and let your LH, FSH, and T rise naturally? Then if your T is still not high enough you start on Androgel or other without any fear of negative feedback causing shrinking gonads and other problems. Also, it would do away with the syringe once and for all except with body builders you could inject T without fear of the litte guys dissapearing.

Baclofen is a relative easy prescription to fill with your doctor as it is considered a safe drug. Now all we need are some human subjects and we may well be on the way to revolutionizing anti-aging,

Oh yeah, you may asking does Baclofen cross the BBB?

ncbi.nlm.nih.gov/sites/entre … stractPlus

Thoughts anyone? Also I wrote Dr. John at allthingsmale.com for his opinion.

Regards,

JTay

#2

JTay, very interesting info and thanks for informing us about this… I see you have been doing more research and posting here:

forum.mesomorphosis.com/mens-hea … t=baclofen

I saw on the MesoRX post you are also a former Finasteride user, good to have you here with us. Hope this forum has been helpful in your search for a cure.

Apparently this study supports the fact that GABA and Baclofen have an impact on androgen production:
blackwell-synergy.com/doi/ab … .tb11416.x

“In addition, the incubation of testicular interstitial cells with GABA and baclofen resulted in an increase in androgen production. These results support a functional role of GABA in the neuroendocrine control of the male gonad.”

Although the first study you mention is an animal model, it would be interesting to see if the same holds true for humans… if you plan on trying Baclofen, please keep us updated as to your progress and further research.

#3

To my knowledge;

Even if this product can work in humans- which is up in the air.

It is NOT used to treat hypogonadism, has NO licence and is NOT used to treat hypogonadism.

It has had NO safety or efficacy testing in humans for hypogonadism.

IF (big if) and when such a product is tested in humans and passes its trials and obtains a licence (primary or otherwise) it can be considered.

To use it prior to such a point would be dangerous and highly questionable and something I don’t think anyone should be suggesting.

If the drug is as good as is being suggested by the original poster then it will come to the fore and we will hopefully see its use.

#4

I just got a script for it today.

#5

Please keep us posted…

#6

I haven’t even seen this thread before. Just more corroboration as to what I, and a few others have experienced using these types of drugs.

#7

Is this considered the same stuff? Sexual dysfunction?

ncbi.nlm.nih.gov/pmc/articles/PMC2435028/

#8

what dose are you going to take iwontgiveup?

#9

BTW are you taking Balcofen or Xyrem? How did you end up getting that written up for you?

#10

I have the script for 60count of 20mg. Last week I took 6-oxo and posted about it another thread. I am also taking Test-E. The 6-oxo hasnt been able to get my estrogen back down so I ordered some Aramosin today. Usually, when the 6-oxo works for my penis my joints also hurt and I am kind of cut all around. However last week I got it up crazy. It LITERALLY grew. Lots of tumescence. RIght now for instacne, I cant get it up for the life of me but it is temescent on the Testosterone (without I cannot achieve any tumescence) I believe currently that I have some serious estrogen dominance currently due the Testosterone. Back to last week - it grew - iknow it did because my (forever patient) girlfriend noticed it too. She couldnt believe that my penis was actually that big because she is so used to a small semi-tumescent erection. This was the real meal deal. I couldnt pound it like I used to it would soften up a bit but I was 90% there. I thought it was because of the testosterone I took a couple days back and its only in hindsight that i now think it may have been the baclofen. I originally got the idea after reading about allopregnenolone and its influence on GABA receptors (the only difference is A vs B). My friend who is an ex-addict had 3 left over and i got them from him. I took them friday, sat, and Monday. Sunday night I was so depressed from the “penis problem” I got wasted at my house (I normally dont drink) and passed out without taking it. Monday night I took the last one. Tuesday I was temporarily cured. I took them at bedside as I was going to sleep for the night. I slept very well compared with usually I am falling asleep fine but waking up tossing and turning by 4-5am.

Wednesday by noon I was f’d again and I hadnt attributed it to the baclofen at that point. I thought it was the testosterone (which I also took IM on Tuesday again and it takes a day or so). And I have continued to take test-now more aggressively but it seems to backfire with extreme estrogen sides. After racking my brain I think to myself - THE BACLOFEN. THATS WHEN I TOOK THE BACLOFEN! (or also I got way drunk and hungover ??) those are only 2 things I did differently.

I made this coorelation on Saturday of Memorial day weekend and called and booked an appt with a doc i know for tuesday. I am going to keep taking 10mg right before I go to bed. I don’t know if that was what did the trick like that but I am in the Baclofens at 80 bucks now with the visit and script and i have blown countless $ at this point and I am down for anything so I can let you guys know if this does anything.

As far as getting it from the doc, this guy is pretty chill here. He is a suboxone registered doctor and my friend went to him and I have seen him a couple of times to get a testosterone shot before i got hooks on it myself. I was just direct with him about my lack of luck with the stupid ass ENDO stupid ass URO stupid ass NEURO etc. I told him the logical connection i made with 5ar, allopreg and with GABA and asked him for Arimidex (for the estrogen) and Baclofen and he told me he cant ethically prescribe me arimidex which is fine because i ordered it myself liquid form and he said he could write me the baclofen. I think he just wanted me to shutup once I got going about my symptoms lol

#11

Yea, dunno if I’d risk Aromasin considering its a permanent enzyme inhibitor, vs Arimidex which is a reversible inhibitor.

healthcentral.com/breast-can … atase-faqs

#12

Yea, dunno if I’d risk Aromasin considering its a permanent enzyme inhibitor, vs Arimidex which is a reversible inhibitor.

Well you have 2 basic types of AIs. Suicidal (permanent) and Reversible. Both will latch on to the aramotase enzyme and disable it however the the reversible AIs will eventually “dislatch” and free up the enzyme again. This can lead to an estrogen rebound when you discontinue the AI. The suicidal AIs basically pull off a kamikaze mission. Since I seem to be especially estrogen prone I think that the suicidal AI is best. I have experience with 6oxo and it is a suicidal AI. The ATD that the gentleman who was cured is a reversible AI but maybe he wasn’t as estrogen prone… who knows. I think they are both pretty similar.

from what I have found, Aromasin is known to reduce estrogen more than Arimidex is overall.
steroidology.com/forum/anabo … midex.html

#13

I think you said it took a few days before you noticed it was having a positive effect - with phenibut I noticed it took around a week before I had a serious recovery. All I knew while I was taking it was it was improving my sleep, until one day I woke up with no more pain and a sharp mind. And as I’ve said before, phenibut and balcofen are basically the same thing.

#14

so why did you stop taking it?

#15

I built up a tolerance - phenibut develops tolerance quickly. Recovery waned.

#16

hmm looks like so does baclofen… did you try to up the dose? How long did it take? I guess this means that either this stuff doesnt cure the problem just resolves it temporarily. unless you need to run it for longer than you did?

#17

Have you already built up a tolerance to the baclofen?

#18

Where do you get this info from? Did you take Baclofen? How do you know it is something you can build a quick tolerance to?

#19

I googled baclofen tolerance and a plethra of info came up

#20

welp cross baclofen off the list