Interesting theory… There is a test for Anti-AChR antibodies in my country for like 20-30 bucks, maybe you can find the same in yours. Haven’t done it but maybe I might in the future
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Sounds leggit!
If it’s that cheap you should get checked them asap and share your results with us, I don’t have that test unfortunately in my country , so wondered whats going on .
These are different antibodies from the one I mentioned.
This is what I tested positive for,
neuronal achr ganglionic (alpha-3)
It will probably cost more then 20 or 30 bucks Im guessing.
The other is used to help diagnose Myasthenia gravis, but they are not the same antibodies even though they look similar.
I am going to have some more time and money in the near future and I might follow-up on this antibody.
How rare is autoimmune autonomic Ganglionopathy?
Approximately 100 Americans are diagnosed with AAG per year. AAG is a treatable antibody-mediated disorder of autonomic ganglionic synaptic transmission.
How is it treated and are you going to treat it?
Did any of you guys had a spermiogram and did it turn high in leukocytes? As I found this evidence on me(more than double the limit), I am now wondering if it is bacterial induced or if it is autoimmune. Will do the seminal colture tomorrow, but if it turns negative, I guess it can only be autoimmune. And in that case I’ll probably check as you did.
It could be both, I also wouldnt call some of these possibilities an infection per se, but maybe a type of shift in balance or triggering event. You see all of these thoughts are within the past couple of years.
I still think this could be the closest organic (or non-drug) type of treatment that could be coming.
Otherwise those antibodies are sometimes treated with IVIG, which wont even be an option for most people.
Why gut bacteria are becoming key suspects in autoimmune …
Feb 2, 2021 — Many patients with PSC have other autoimmune diseases, and some of the genes associated with the condition are also linked to autoimmunity .
Bacterial infections are associated with many autoimmune diseases involving chronic inflammation and demyelination. The possible mechanisms of bacterial involvement as aetiological agents or in the exacerbation of these diseases have been investigated intensively.
Could a bacteria-stuffed pill cure autoimmune diseases?
https://www.nature.com › outlook › article
](https://www.nature.com/articles/d41586-020-00197-z)
Jan 29, 2020 — Could a bacteria -stuffed pill cure autoimmune diseases? Researchers are investigating how the community of microbes living in the gut might …
Triggers of Autoimmunity: The Role of Bacterial … - Frontiers
https://www.frontiersin.org › fimmu.2019.02608 › full
](https://www.frontiersin.org/articles/10.3389/fimmu.2019.02608/full)
by CC Qiu · 2019 · Cited by 20 — Moreover, bacterial infections can release bacterial DNA associated with other bacterial molecules, complexes that can elicit autoimmunity by acting as innate stimuli of pattern recognition receptors and activating autoreactive B cells through molecular mimicry.
Researchers Discover New Link Between Autoimmune …
https://www.infectioncontroltoday.com › view › researc…
](https://www.infectioncontroltoday.com/view/researchers-discover-new-link-between-autoimmune-diseases-and-gut-bacterium)
Oct 29, 2018 — The culprit in this case is called Bacteroides fragilis, a bacterium that normally lives in the human gut. The Queen’s team has shown that this …
The enemy within: Gut bacteria drive autoimmune disease …
https://news.yale.edu › 2018/03/08 › enemy-within-gut…
](https://news.yale.edu/2018/03/08/enemy-within-gut-bacteria-drive-autoimmune-disease)
Mar 8, 2018 — Bacteria found in the small intestines of mice and humans can travel to other organs and trigger an autoimmune response, according to a new …
Gut bacteria may hold key to treating autoimmune disease
https://researchfeatures.com › Health & Medicine
](https://researchfeatures.com/gut-bacteria-key-treating-autoimmune-disease/)
May 31, 2018 — Emerging research supports that the gut bacteria influence various immune cells in autoimmune diseases. The precise mechanisms of how and …
How rare this antibody is btw,
Ganglionic Acetylcholine Receptor Autoantibody
Oncological, Neurological, and Serological Accompaniments
Of 15 000 patients tested on a service basis, 1% were seropositive
Other Autonomic Neuropathies Associated with Ganglionic Antibody
The identification of the acetylcholine receptor ganglionic (G-AchR) antibody by Vernino et al. in 1998 and especially following the comprehensive study in 2000 opened a new era in the diagnosis, evaluation, and treatment of the autonomic neuropathies.
The autoimmune disorder was suspected in the original description (Young et al., 1969, 1975) when it was considered as an autonomic variant of Guillain-Barre’ syndrome. The view was sustained in the Mayo Clinic experience, where we demonstrated selective involvement of C fibers, an inflammatory, presumed immune attack of nerve and possible response to immunotherapy
This could be another possible marker.
Antiphospholipid Syndrome as a Neurological Disease
Neurologic disorders are among the most comum and important clinical manifestations associated with the antiphospholipid syndrome (APS), mainly those that affects the central nervous system (CNS). These include sroke, transient ischemic attack, Sneddons syndrome, convulsions/epilepsy, dementia, cognitive deficits, headaches/migraine, chorea, multiple sclerosis-like, transverse myelitis, ocular symptoms and Guillain-Barre syndrome.
Anti-phospholipid antibodies in serum from patients with Guillain-Barré syndrome
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Of 15,000 patients evaluated at the Mayo Clinic for paraneoplastic autoantibodies in a 27-month period, α3-AChR Ab values exceeded 0.02 nmol/L in 155 patients
Mine was 0.07
It didnt copy and paste too well but you see how getting a few simple blood tests run could maybe start to paint a picture or help diagnose when most are saying there is nothing wrong with you.
“Since incorporating the α3-AChR Ab assay into the standard Mayo Clinic serological evaluation for paraneoplastic autoimmunity in 2005, we have observed that this Ab has broader oncological and neurological associations than originally recognized.”
Neurological Associations in 155 α3-AChR Ab–Seropositive Patients by Titer
|Neurological Manifestation
|Peripheral nerve, autonomic(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764484/table/T2/?report=objectonly#TFN8)|17 (20)b|6 (10)b|
|Limited dysautonomia|20|3|14|3|
|GI dysmotility|10c|1|8|1|
|Orthostatism|5|1|3|1|
|Anhidrosis|3|1|1|1|
|Sicca syndrome|2|0|2|0|
|Pandysautonomia|13|7|3|3|
|Peripheral nerve, somatic|44 (28)|0|31 (36)|13 (22)|
|Sensorimotor polyneuropathyd|28|0|22|6|
|Small fiber sensory neuropathy|7|0|5|2|
|Polyradiculopathy|4|0|2|2|
|Cranial neuropathy|3|0|1|2|
|Sensory ganglionopathy|1|0|0|1|
|Multifocal motor neuropathy|1|0|1|0|
|Neuromuscular junction|4 (3)|0|1 (1)|3 (5)|
|Myasthenia gravise|4 (3)|0|1|3|
|Central|26 (17)|1 (8)|20 (24)|5 (9)|
|Cortical and/or neuropsychiatric|15|1|11|3|
|Movement disorderf|5|0|5|0|
|Demyelinating CNS disorders|5|0|3|2g|
|Stiff-man syndrome|1|0|1|0|
|Nonautoimmune disorder or noneh|48 (31)|1 (8)|16 (19)|31 (54)|
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Anyway this could explain how guys can take massive amounts of steroids and still not feel muscular or sexual effects?
Yes they diagnosed high dose white blood cell in my urine and I though it is prostatitis, must be anything important.
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Let us know about updates boss.
I’ll never ever understand, you can give testosterone dianabol whatever to people who are brain dead and they’ll still probably grow muscle and stuff. For us, nothing
This is how it may be treated considering the thought that these diseases could be related.
**The autoimmune disorder was suspected in the original description (Young et al., 1969, 1975) when it was considered as an autonomic variant of Guillain-Barre’ syndrome.
**The view was sustained in the Mayo Clinic experience, where we demonstrated selective involvement of C fibers, an inflammatory, presumed immune attack of nerve and possible response to immunotherapy
Guillain-Barre Syndrome Treatments
Policy
-
Aetna considers any of the following therapies medically necessary for the treatment of Guillain-Barre syndrome (GBS):
-
Intravenous immunoglobulin (IVIG) when criteria in CPB 0206 - Parenteral Immunoglobulins are met.
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Outpatient pulmonary rehabilitation program when criteria listed in CPB 0032 - Pulmonary Rehabilitation are met.
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Plasmapheresis when criteria in CPB 0285 - Plasmapheresis/Plasma Exchange/Therapeutic Apheresis are met.
-
Aetna considers the use of any of the following therapies for the treatment of GBS experimental and investigational because their effectiveness for this indication has not been established (not an all-inclusive list).
-
Acupuncture
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Alemtuzumab (CPB 0764 - Alemtuzumab (Campath))
-
Amantadine
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Bifidobacterium infantis
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Brain-derived neurotrophic factor
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Cerebrospinal fluid filtration
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Corticosteroids
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Eculizumab
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Interferons (CPB 0404 - Interferons)
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Leukocyte trafficking inhibitors (e.g., efalizumab, etrolizumab, natalizumab and vedolizumab)
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Neuromuscular electrical stimulation in rehabilitation of GBS
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Per-oral endoscopic myotomy (for the treatment of GBS-associated achalasia)
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Rituximab
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Sugammadex.
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Got the results of the colture, no bacterial infection. I will repeat that in another lab to confirm the result. If it is confirmed, it’s time to investigate the real cause but it gets more complicated. I suffer from lower back pain too. There probably is a connection.
I also got an MR of the pelvis area. The prostate apparently is normal, no sign of inflammation, the seminal vesicles too.
I’d get urine/semen colture too at your place.
This thing is very expensive. This is the first obstacle for me. But I’m sick of it and will spend all what I have to find where is the problem.
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Leaky gut and family is still a bit controversial. It is often mentioned as a cause for a lot of illnesses. A lot of hype, in my opinion it should be taken seriously although keeping your hope in stand-by. I am being treated for that since a few days, my endo suggested a supplement (Hericium erinaceus, quercetine, niacine, biotine). I’ll see if something changes. I don’t have tests to demonstrate I suffer from leaky gut but will do soon.
As for the autoantibody part, can’t say much at this time really. I’d need to study.