Here is a post that I have read before.
Well it seems to be true based on another study I posted where women on high dose HMG HCG increased their hormone levels but decreased their adiol-g levels.
But I have some questions. If one does have too much aromotase in his testicles, adrenals or perhaps estrogen producing tumor what about when he injects T. Surely there is good blood glow to the testicles? It looks like tere are very signifigant veins connecting to the testicles so wouldnt the T end Up as e2 though circulation though the testicles?
Another issue this brings up is if one takes an anti E his LH may suddenly increase a lot and proceed to produce too much hormone from the testicles which may lower adiol g? Then one has to take into account the SHBG fluxuations during these hormonal changes. It leaves a pretty complicated picture.
I have taken a heavy dose of arimidex before and very quickly I started having suicidal thoughts but from what I understand - e2s half-life is quite long so I cant imagine my circulating E2 dropped like a rock in hours? So too much ai could indeed cause problems in some parts of the body. Sometimes I get a pain in my sholder even on a small dose of AI.
Post from KsMan on tnation
Concerning higher dose hCG or hCG mono therapy HRT:
There are problems when using larger amounts of hCG. The concentration of T inside the testes, intratesticular testosterone [ITT], can be up to 80 time greater than serum [blood] levels. At least that is seen in young health men.
Most aromatase inhibitors are competitive drugs that interfere with testosterone getting reacted by the aromatase enzyme. This means that one needs a concentration of anastrozole that balances testosterone levels. The higher ones T levels, the more anastrozole is needed. This is a linear relationship.
There is a lot of aromatase in the testes. As men age, levels of aromatase increase and there may be an increase of aromatase inside the testes as well. The testes are a small part of the body, but ITT can significantly leverage the affects of aromatization in the testes.
If you have a level of anastrozole that is appropriate for the serum T levels, and if ITT was 80 times higher than serum levels, the anastrozole levels in the testes could be out numbered 80:1. With high doses of hCG, ITT levels could be more than 80 times higher than serum levels. Also note that high doses of hCG risk LH receptor down regulation… a major step backwards.
Anastrozole is not effective in controlling T–>E aromatization in the testes. When guys take larger doses of hCG, E production in the testes can be high. Taking more anastrozole will not reduce that, but one then pushes down T–>E production rates in the peripheral tissues of the body. We have some who have been taking high amounts of anastrozole who cannot get their serum E2 near [optimal] E2=22pg/ml.
High does of anastrozole can be costly and may create some side effects as reduced T–>E aromatization in the brain may have some negative effects as the E levels in the brain may become lower than what is normally associated with serum E2=22pg/ml with normal anastrozole doses. In this case the ratio of anastrozole to testosterone in the brain is too high. One could state that this is true for all of the body except the testes.
If you are using more than 250iu hCG SC EOD and you cannot manage E2 levels with normal doses of anastrozole, consider using less hCG. When doctors use high dose hCG as a mono therapy [high dose], even if they achieve descent serum T levels, E2 may be big problem and high doses of anastrozole may create mental/mood and libido problems. In this case the doctor is optimizing a T response and not looking at or understanding the big picture.
Do not consider hCG to be a source of T. Use lower dose hCG to maintain the health of your testes and change T dosing to achieve target serum T levels. For those who have been stable without hCG who then add hCG later, the amount of increase in T levels with hCG probably is a good measure of how much E is also produced in the testes and a measure of the potential for higher amounts of hCG to create problem