Internal studies of Roche isotretinoin Accutane

Hello,
I’m adding a summary table of Roche’s internal studies on gastrointestinal disorders (uncovered during trials in the US). Data extracted from the case law : https://law.justia.com/cases/new-jersey/appellate-division-unpublished/2016/a1236-13.html
to see also :
https://www.fichier-pdf.fr/2025/05/09/case-law-on-ulcerative-colitis-ibd-suicide-and-roaccutane/

An internal study pre-1982…reveals percentages very, even too close for
Vesanoid (tretinoin): 21% versus 34% (anticancer chemotherapy: see, another study between
1982 and 1998 demonstrates causality with the highest possible level of evidence.
Never replicated…

Strangely, compared to the multitude of studies on large population samples regarding depression (more profitable and more covered in the media, with endless debate),
no study has ever been conducted on a large scale on gastrointestinal disorders, yet
with exactly 12% of pharmacovigilance reports worldwide for each of the two diseases.

It’s no coincidence that all the trials in the USA focused on gastrointestinal disorders, of the “second brain”.

And what about the very close 11% of disorders dermatological, for baldness, alopecia, etc., before the age of 20?

Can’t this cause depression too?

Especially if you have gastrointestinal disorders as well?

Can gastrointestinal disorders cause dermatological disorders?

Is there a cause-and-effect relationship between these three diseases/side effects? In what sense? Which is the goose , which are the eggs?

We’ve studied and monitored the egg of the goose that lays the golden eggs a lot… but we’ve never studied and monitored the goose (gastrointestinal disorders).
Is this reasoning sound or not?
To me, that would explain a lot: a complete smokescreen.

When the wise man points at the moon, the fool looks at the finger. The labs and drug safety agencies have understood this well: the finger represents the communication of the ANSM and the MHRA, as well as the media, most of which only talk about the sensational side effects of depression and suicide, but especially not about anything else (the most recent being Guillemette Franquet, who came to the Facebook group looking for prey and lied to me when she told me she wouldn’t only talk about the depression side effect. I wasn’t expecting anything from a journalist, but I was still disappointed by her predictable manipulation).

Oh yes, now, the sexual effects, the big deal, the sham… the side effects of gastrointestinal problems.

This little game has been going on for over 40 years.