-Broccoli contains a compound called “sulforaphane”.
-HDAC and DNA methylation work together to control normal cell function (both are “epigenetic mechanisms”)
-DNA methylation can turn cell/genes “off”.
-“Sulforaphane” has been found to work both as a HDAC inhibitor and also a promoter of de-methylization.
Study was published in the Journal of Epigenetics a few weeks ago.
Anna Hsu, Carmen P Wong, Zhen Yu, David E Williams, Roderick H Dashwood, Emily Ho. Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clinical Epigenetics, 2011; 3 (1): 3