Interesting observation about proviron

Therapeutic Efforts
#1

i want to share a strange but very interessting observation about proviron(syntetic dht)

a while ago i bought some proviron and wanted to try and see if i get any improvement,then decided that i would rather wait for andractim to try first

a friend of mine who used an antiandrogenic medication to cure his puberal acne got the same symptoms we all have (ed,fat gain,pseudogynecomastia ect…) and that lasted to the age of 30

i told him about proviron and that it could potentially improve his symptoms,he agreed to try it for two weeks
after the initial two weeks he have seen no improvement at all and told me it was like he was taking candies, so he stopped

a week after that he decided to try it again for few days then stopped again, he told me that he got a strange reaction that he couldnt explain,like extreme thrist

a few weeks later i’ve met him and i was extremly suprised by the phisical change he got…he got from fat with manboobs to ripped with almost no fat and apparents veins all around with no traning ,he also told me that his libido got from non exixtant to bothersome

i couldnt explain the reaction
the first question is why the first time he tried it he got no improvement at all,and only after he stopped and restarted that the changes was so drastic

it seems that the stop then restart has tiggered something at an epigenetic level

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Thick semen & watery semen & no force
#2

Hey, thanks for mentioning this.

I’m assuming your friend took Accutane for his acne, and it left him with PFS-like symptoms?

This is interesting to me because I have read about a few fellow post-Accutane patients who tried DHT analogues. One supposed recovery (within 14 months of stopping Accutane) and several non-recoveries. One person I spoke to on a regular basis had an initial recovery taking proviron, which faded away with continued use.

Please have him join this forum and share his story. We would all like to know if this recovery of your friend’s lasted or if it was only a temporary effect.

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#3

When did it start?

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#4

Uh. Interesting thread. Wish your friend posted a recovery story here. @kaisus are you still here?

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#5

This exact same thing happened to me. Took it and didn’t feel anything for 3 weeks and then i started feeling androgens. That proviron probably downregulated his upregulated receptors and it took some time. Is he still on proviron?

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#6

Thos is very interesting and could explain a lot

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#7

Yeah, the common theory: our receptors got upregulated with anti androgens, androgens does the opposite. Obviously trt is a very weak one no wonder not having any effects of it, but dht being 5 times more powerful than trt can do downregulate it…

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#8

Well yes but as you can read, that guy took an anti- androgen. Probably Accutane.

So his problem was downregulated AR’s. And Proviron would downregulate them more which is not good at all.

So it is strange to me how he recovered with it. Maybe his problem was hormonal, not receptor damage. Who knows though! Human body is very complex.

Proviron didn’t work for me, i felt bad on higher dosages of it. But i remember the first 2 week cycle on just 25mg, and i felt good. But nothing lasted.

#9

It just takes more time for the body to properly respond, I would imagine.

The androgen receptors are either upregulated (are dense, and responses are sensitive, causing negative symptoms), or downregulated (not cuasing enough of an effect, in other words no effect.

What the probable issue is, at time of using Proviron, I don’t know yet*, but I believe longer term use >6 months will probably restore normal function.

  • in penile skin of pfs sufferers the androgen receptors were denser, there were more of them, compared to non pfs sufferers. And it is theorized that happened due to 5 alpha reductase causing androgen deficiency, and resulting in upregulation of the androgen receptors.

My current theory: The upregulation of androgen receptors is probably a way for the body tocmake sure any androgens still in the system are sure to bind to the tissues. But when increasing the androgen load once off finasteride, some or most of those receptors become desensitised or silenced, potentially causing mild/partial androgen insensitivity. Causing the Proviron to not have an effect, until the receptors are re-sensitized. This probably won’t happen in two weeks.

If androgen receptors are too much downregulated, upregulation must happen first for it to work, done with other supplements for example Tribulus.

// Not a medical professional, so please don’t take my word for it, it’s merely my deduction from everything I’ve read on here in the last three weeks dealing with this disease. You should definitely research this yourself, to verify if this theory rings true for you with sdditional research, or you’ll risk making your situation worse then you’re now. //