Gut health expert Grace Liu was interviewed on the latest episode of the Paleo Solutions Podcast. At one point she mentions a hormone product taken by women which caused major problems for many people. She then said 5-alpha-reductase inhibitors cause the same problems in men - specifically breaking the HPA axis.
It’s a little hard to follow what she’s saying a lot of the time, but it seems the solution for these problems would be to fix adrenal & gut health.