In Search of a cure for Post Accutane Syndrome

Member Stories
#88

Hi guys,

I thought I give a short update. I crashed about a month ago from eating a chocolate bar. I took my usual supplements and what helped getting rid of that crash was metamizole.
Last Saturday I ordered ALCAR. I did take normal L-carnitine on Saturday, that made me extremely tired on Sunday. From Monday to Thursday I took ALCAR which made me tired as well and my anhedonia worse. That is unfortunate because some users reported that it helped them after about 2 month. I won’t take ALCAR again. I’m waiting now to get back to my baseline.

I have read on Reddit that Lithium helped some people. That is the first thing I saw for PAS patients which many had a positive response. I will try to get that next week.

Best regards

#89

Update: I’m on lithium carbonate 400 mg since Monday. I have seen no improvements so far. I still am crashed from the Acetyl-L-carnitin with a persisting headache. It’s pure torture.
I have ordered Inositol, some PSSD cases healed by it and also one PAS case on reddit.

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#90

Hi guys,

I’m basically cured of most of my symptoms. It’s due to the inositol.
I no longer have brain fog and I experience emotions perhaps not as strong but I have a variety of them.
Sexually wise: I have morning wood, spontaneous erections, no more shrinkage and sometimes genital sensations like a little pleasure, but mostly my orgasms are flat.
I took 9 g of inositol for 5 weeks. I took 4 times 2250 mg daily of a mixture of myoinositol and d-chiro inositol. I at the same time took also 400 mg of lithium carbonate, so it could been also the combination of the 2.
What I still struggle with is blank mind, but I don’t know if that is really a symptom, because some people don’t have an inner monologue, I read a study about this.
I’m very happy with the development and try to attend my oral law exam which is in 3 weeks.

In my next post I explain a possible pathway.

#91

I think how it is working is by increasing beta-catenin. Inositol is part of the PI3K/Akt Pathway. With more of inositol this pathway runs better. That means more Akt which inhibits the destruction of Beta catenin. There is actually a crosstalk between the PI3K/Akt Pathway and the Want/beta-catenin pathway. In particular if you upregulate the PI3K/Pathway you upregulate the Wnt/beta-catenin pathway. So what is the benefit of more beta-catenin? Beta-catenin goes to the nucleus of the cells. It stops repression of gene transcription and it loosens chromatin. With this loose chromatine actually there can be made epigenetic changes and I think these epigenetic changes are the reason why people are feeling better.
I have also just read that more beta-catenin is affecting the Androgen Receptor. More beta-catenin is going to the LBD of the AR. That changes the transcriptional function of the AR. And beta-catenin makes the AR more sensitive to Androgens.

#92

Hi Thommy, how are you doing now?

Do you feel recovered?

And are you still taking Inositol?

#93

Hi,
I’m doing good at the moment. I have passed an oral law exam yesterday.
I’m not recovered. I still have symptoms. For example the emotions I know I have different ones during the day but I always experience them kind of on the periphery.
I still take 400 mg lithium carbonate and 2250 mg inositol daily.