Well usually when someone does there appears a blue check mark at your name…
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I’ll take it in the next couple of days . It’s on my to do list
Good luck and let us know, praying for your and everyone else
I’m halfway through it. Shit is long
I don’t expect it will, but I’ll keep you updated.
I’m a little concerned that this experiment won’t last long. I just finished day two and I’m experiencing moderate cramping in the muscles in my face. Like my jaw feels tight and my upper cheek muscles are literally cramping all the time. I also seem to be developing a rash on my face. Anyway, we’ll see how things go tomorrow.
Quick follow-up - This was a really bad idea. I’m pretty sure I’m experiencing another crash. I have widespread pain all over my body and numbness and tingling in my extremities. I have pain in my testicles, cramping in my facial muscles, and have for the first time in a while experienced a panic attack after 4 hours of sleep at night.
After quick research, this only emboldens my theory that this is a widespread lupus-like autoimmune disorder. According to this journal - https://pubmed.ncbi.nlm.nih.gov/28499587/ - Apremilast increases LacNAc dendritic cell function which can have the opposite effect and increase the activity of TH1 & TH17 - based T cell responses.
I really think that all of these things that we try to do to fix the problem just make it worse by activating our immune systems to cause widespread inflammation and attack various tissues in the body. This would explain why many people who take Apremilast experiencing worsening conditions in their psoriatic autoimmune disorders - https://www.drugs.com/comments/apremilast/
I can’t help but feel like we’re screwed and that until we’re able to cure MS and lupus and all of the other awful autoimmune diseases, we’re just going to be running in circles making no progress. Sorry to be the downer everybody. 
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Yes agree, inflammation is very understated here, i beleive its 70% causing us symptoms. Even asprin is used for reducing inflammation.
Do you think FMT will work ?
One thing ive noticed is since PAS I have never gotten a cold or flu…has anyone else experienced this or why do you think this is ?
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@LifeOnHardMode sorry to read this mate. I’ve had rheumatoid all of my adult life. I reacted positively to all prescribed drugs from the age of 14. PFS came along at 33 then I started to develop reactions to immune suppressers. Not knowing I had PFS. I don’t think PFS has similarity with other immune disorders. PFS does not appear to respond favourabley to any auto treatments. Its basically the opposite with PFS. PFS in some sufferers reacts / attacks everything. Something that wipes out the immune system in one go like chemo is maybe the answer but a very risky approach. A gradual lowering of the immune system gives it legs it’s extremely sensitive our reactions to trace amounts of minerals, vits etc . This is one fucked up disease hope you return to your baseline soon. Best of luck
I’ve never had a cold since aged 14 so was already in that room with rheum which I believe predisposed me. Rheum is classed as a very destructive disease and I had it severe. Even at its worst it never came close to PFS.
I can safely say that controlling chronic rampant inflammation has done me wonders. Took me years to figure this out but I’m glad I finally did. Inflammation is a normal process but chronic or extremely high inflammation isn’t. It causes adrenal fatigue over time, which causes further issues down the road, it’s a downward spiral. Ever wonder why many complain of worsened mood post workout? Most suffereres would look at the end of chain symptoms like depression, anxiety, anhedonia, low libido, ED and whatnot, and try and fix these with more medications/supplements. I know I did and all it did was set me back and forth. Getting to the root cause is the cure and in this instance it’s likely gut dysbiosis. I’ve had my share experimenting with various antibiotics and probiotics to modulate my microbiome and it’s a long slippery road. I’m yet to try FMT route after securing a young healthy donor and I think I’ve found one! I also need to find a reputable clinic for the procedure. I came across some DIY experiences but in no way going to try it.
Yes same I never got cold since pfs, and according to researches th1 dominance people hard to get cold.
Likewise. Didn’t catch a cold/flu/strep throat/sinusitis/…etc., in like 7 years. However, I’ve had nearly every increased inflammation symptom in the book. Food sensitivities, chest tightness/pressure, headaches/head pressure, tinnitus, post nasal drip, stuffy nose, itchy skin, post exercise fatigue, joints pain, variation in body temperature among others. I solved most of them within a year.
My hypothesis is that it’s not always Th1 or Th2 dominance per se. It’s more like anti-inflammatory vs. pro-inflammatory cytokines in general. There’s also Th17 and probably others.
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Are you cured now on your anti inflammatory regime? Im currently attempting the same.
Let me break it down:
Itchy skin + post exercise fatigue + joints pain + chest pressure + head pressure + IBS/GI problems + depression/anxiety + tachycardia + shortness of breath + hypoglycemia are all but gone.
Post nasal drip + morning stuffy nose + morning tinnitus + body temperature: improved greatly but I’m still working to clear them 100%
It’s near impossible to cure symptoms A, B, C, E…X, Y, Z, W in one go. That’s why it’s important to track your symptoms as they resolve since we have tendency to forget over time.
@surviveplz
Did you read the study in which SRD5A2 was regulated by inflammatory cytokines? The question is… how to inhibit them potently enough. Elimination of all inflammatory triggers is surely a start. Im adding peptides aswell.
TNF-a inhibitors are dangerous, they can lead to MS-like diseases.
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Can you please explain more on SRD5A2?
Its the 5 alpha reductase gene, it is regulated by TNF-a, IL-6 and Nf-kb… at least in in prostata tissue. If this is true in other tissues, it would mean you could reverse silencing of 5 alpha reductase by lowering inflammation.
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Prostata
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