There are certainly some aspects to PFS which make the AI theory plausible
- For some PFS happens after REstarting finasteride; maybe the adaptive immune system has been primed by the first period of finasteride usage (like a vaccination)
- An explanation for the first time users developing PFS would be their immune system has already been primed by another 5ARI, in their diet for example (herbs etc)
- People getting PFS from a single, or just a few pills
- The American guy feeling substantially better after high doses of methylprednisolon; a strong AI suppressor
I’ve probably come across more supporting phenomenons, but can’t remember at the moment.
On the other hand, if PFS would really be treatable with an AI suppressor we would probably know by now just by coincidence.
More plausible would be there’s permanent damage through an AI mechanism, which cannot be cured by AI suppressors because the damage has already been done (like in multple sclerosis for example).
But Laz, regarding why people get worse or fluctuate, I think there’s a clear explanation. The male body has been used to working with a normally functioning androgen system for years and then suddenly it’s all messed up, some tissues and systems will show marks of deterioration over different time frames because they slowly get worse. Many tissues need high levels of androgen stimulation to keep functioning.
I’m personally not convinced it’s AI mediated but it’s certainly still a possibility.