You may be on to something. I decided to look into this and interestingly enough, Ibuprofen has been linked to decreased Alzheimer’s Disease risk:
Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer’s Disease
Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro
sciencedirect.com/science?_o … 2658f2b167
(this is more related to Parkinson’s, but they do mention AD)
Now, you may be asking why I mention Alzheimer’s… well, the symptoms of Alzheimer’s seem to be similar to those of “brain fog” from Finasteride: changes in mood and behaviour, memory impairment, cognitive dysfunction, speech issues, mental decline, depression, anxiety, confusion, paranoia etc.
Read symptom details:
helpguide.org/elder/alzheime … stages.htm
Also, this post from another member who received a response from a doctor (supposedly) on a web forum somewhere, concerning Finasteride, Allopregnanolone and demyelination of neurons: propeciahelp.com/forum/viewtopic.php?t=188
Now, here is my theorizing with regards to Finasteride use:
As per this posting citing concerns about decreased Allopregnanolone and neurodegenerative diseases such as Alzheimers, Niemann-Pick etc ( propeciahelp.com/forum/viewtopic.php?t=38
… it is also interesting to note reduced Allopregnanolone levels may play a part in Alzheimer’s to a certain extent:
The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer’s disease
Regenerative potential of allopregnanolone.
biomedexperts.com/Abstract.b … egnanolone
So, tying it all together:
We took Finasteride, which impaired Allopregnanolone neurosteroid production while we took it
Low Allopregnanolone levels may potentially be involved in Alzheimer’s pathology
Ibuprofen use has been found to help reduce the risk of Alzheimers, and reduce neuronal plaques in an Alzheimer’s mouse model
Members in this thread are stating Ibuprofen use improved their impaired mental/cognitive symptoms, just as Ibuprofen use has been linked to a positive effect on Alzheimer’s prevention or progression
Now, I am not advocating people jump on a daily regime of Ibuprofen use… I was simply trying to see if there was a logical connection to be made between Ibuprofen use and what people described in this thread with regards to improvements in mental side effects. There are many dangerous side effects (including kidney damage and stomach bleeding) from longterm use of Ibuprofen and debate still rages in the medical field wether it should be prescribed for a disease some people may or may not get decades later.
The good thing is: Allopregnanolone is also involved in neuroregeneration and neuroprotection.
Many people’s anxiety and depressive symptoms cleared up shortly after discontinuing Finasteride (Allopregnanolone no longer inhibited)
Members are able to get drunk again after quitting Finasteride (alcohol increases Allopregnanolone synthesis; when taking Finasteride the drug inhibits Allopregnanolone and prevents feeling drunk… after quitting Fin, Allopregnanolone can once again be synthesized to activate GABA-A receptors to give you the drunk feeling – I can personally attest to this one)
Members’ slow but steady improvements in mental function the longer they’ve been off
… it seems likely that it is a gradual process for the brain to “repair” itself from the damage Finasteride caused, now that Allopregnanolone is likely functiong correctly again.
We can probably help speed healing further via natural supplements, excercise (cardio especially) and diet as mentioned below. Again from bio.net/bionet/mm/neur-sci/2 … 58929.html
Looking for natural strategies to help prevent Alzheimer’s, if you do research on “Alzheimer’s diets” or foods, you’ll come across a bunch of info, some of which was listed here: propeciahelp.com/forum/viewtopic.php?t=2237
Make sure you take Omega-3 fish oil supplements! Also, apparently ketogenic diets seem to help with minimizing seizures (for those with muscle twitches), and have been linked to improvements in Alzheimer’s plaques.
In addition, I also came across mention of extra-virgin olive oil acting similarly to Ibuprofen:
Ibuprofen-like activity in extra-virgin olive oil
nature.com/nature/journal/v4 … 7045a.html
Olive oil component has ibuprofen-like activity
Olive Oil Contains Natural Anti-inflammatory Agent
thyroid.about.com/b/2005/08/30/o … -agent.htm
So make sure you eat your olives. A mediterranean diet may be just what the doctor ordered.