Methylation inhibits Estrogen receptor, ERα
ERα controls smooth muscle cells in penis.
Test Folate,RBC per the article below. My Folate,RBC tested at 715 (range 140-628). I took Accutane, THC, MB12 which are all anti-folate substances
“Higher RBC folate levels were associated with higher levels of both ERα (P = 0.03) and SFRP1 methylation (P = 0.01)”