Hypermethylation of ERα & Smooth Muscle Cells

Methylation inhibits Estrogen receptor, ERα

ERα controls smooth muscle cells in penis.

Test Folate,RBC per the article below. My Folate,RBC tested at 715 (range 140-628). I took Accutane, THC, MB12 which are all anti-folate substances


“Higher RBC folate levels were associated with higher levels of both ERα (P = 0.03) and SFRP1 methylation (P = 0.01)”