Link: antiaging-systems.com/a2z/hydergine.htm
Hydergine stimulates oxygen flow to the brain, relieving symptoms of deteriorating mental capacity
Upregulates Serotonin & Dopamine Receptors
Hydergine is an ergoloid mesylate (derived from rye) and it has become one of the world’s most useful and popular ‘smart drugs’. It is known to have all the following effects:
Increase blood supply to the brain.
Increase oxygen delivered to the brain.
Enhance metabolism of brain cells.
Protect the brain from insufficient oxygen supply.
Slow the deposit of the age pigment lipofuscin in the brain.
Prevent free radical damage to brain cells.
Increase intelligence, memory, learning and recall.
Oxygen and the brain
Either too much or too little oxygen can upset the balance and generate the production of free radicals, which in turn can lead to aging. One of the major ways in which oxygen generates free radicals is its reaction with unsaturated fats, a process called peroxidation. Brain cells contain more unsaturated fats than any other part of the body, therefore it is our brains that are most susceptible to peroxidation.
Peroxidation and the formation of massive amounts of potent free radicals can occur during heart attacks, stokes and through the effects of smoking and pollution. Consequently, many countries use Hydergine for emergencies and accidents that involve heart attacks and strokes. Hospitals give Hydergine to patients before an operation in order to gain time in case of any ensuing crises. This is because Hydergine helps to stabilize brain oxygen levels, if they are too high Hydergine lowers them, if they are too low then Hydergine improves them.
This effect was demonstrated when two groups of cats were anaesthetized and their brains electronically monitored. The scientists reduced the brain’s blood supply (and therefore oxygen supply). The cats in the control group (with no Hydergine ) had brain damage within 5 minutes and died within 15 minutes. However, the cats in the pre-Hydergine treated group had strong brain wave patterns up to 45 minutes later. This experiment proved two things. Firstly, that a decrease in the normal oxygen balance results in tremendous free radical damage; and secondly, that Hydergine protects against this free radical damage when the oxygen level is upset.
Rejuvenation properties
There is also evidence that Hydergine stimulates the growth of dendrite nerve fibers. Dendrites can normally be expected to decline with aging and some scientists have associated the number and density of dendrites with intelligence.
A group of Italian scientists have studied the ultra-cellular features of synaptic mitochondria (contains enzymes for respiration and energy production) to see if long-term Hydergine treatment could delay or prevent the loss of synaptic connections. The scientists found that the number of mitochondria are greatest at about 12-months of age in rats (equivalent to a 25-year old in human terms) and then progressively decreases. However, the size of the mitochondria increased progressively after 12 months. Thus in young adult rats, the energy required at synaptic regions is provided by a large number of small, highly efficient mitochondria, whereas in old rats, energy is produced by a smaller number of larger, less efficient mitochondria. After treatment with Hydergine, it was seen that the total mitochondrial volume of old rats was nearly the same as the young rats. Furthermore, the mitochondrial was altered to a size more youthful.
Dosage:
Usual dosages are 2.25mg to 9mg daily, but always build up the doses slowly. We offer hydergine in 4.5mg tablets (which are scored so that half a tablet or 2.25mg can be taken). We also offer a more easily absorbed liquid hydergine, which provides precise titration because dosages of 0.5mg increments can be taken. Liquid hydergine is also less likely to cause any stomach upset.
Side effects:
Side effects even quite high dosages have few side effects as long as the dose is gradually built up. Otherwise side effect of nausea and headaches may occur.