[Size=4]Human type 3 5a-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride[/size]
Thanks to the user “tryingnottoworry” for digging up this important 2010 article.
Scientists have recently discovered 5AR3 enzyme in humans, as noted here: viewtopic.php?f=9&t=4875
It turns out 5AR3 is expressed in higher concentrations across numerous body systems, vs 5AR1 and 5AR2 (which Finasteride is known to inhibit). According to this paper, Finasteride and Dutasteride also potently inhibit 5AR3.
PDF of the paper and excerpts posted below. Time for the FDA to mandate a prescribing label change for both these drugs.
2010 - Human type 3 5a-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride.pdf (372 KB)
