My experience is a bit more positive, but it took time. Initially, almost my entire family were dismissive of PFS, except for my mum. It created a lot of resentment for me, particularly for my sister-in-law who actively challenged me with some “toughen up” bullshit in the early days of my crash when I was on suicide watch 24/7.
Time has helped a lot. They’ve seen me crash, seen me not improve back to who I once was, and seen the emerging body of medical literature. My video I created earlier this year helped articulate the impact this has had on my life, when I may have otherwise struggled in person.
I would also show your family, if you haven’t already, the literature review from Axo and Awor, which even talks about how interfering with the same pathway can cause permanent worsening in some patients. Unfortunately this isn’t documented anywhere in medical literature, but the 20 year patient record on this forum alone demonstrates that.
I would also show your family the six patient stories on our YouTube channel. This gives them other real humans talking about the condition, who clearly did not have prior health histories. You could also show them the stories of those who are no longer with us - men like Daniel Stewart (a professor of crimonology), John Pfaff (a successful technology executive) and Romain Mathieu (a prospective investment banker studying at a selective business school). These men all took their own lives due to PFS and clearly were accomplished and intelligent men with no prior health problems.
Baylor results could also help in demonstrating this is an extremely complex health problem.
And finally, I think as you’ve already done, continuing to empathise with them is important. We know as patients this is counter-intuitive and extremely difficult to understand, which is why we live with it daily. If it were simple and straight forward, none of us would be in this mess. Communicate that to them, and give them time. Kill them with kindness, so to speak.