How do children sexually develop?

Necro · May 25, 2018, 7:34am

I just had this idea how does puberty work and how does that develop children into men? What signals the brain for this to occur? If you could recreate the hormonal/chemical responses in children when they are going through puberty perhaps that might be an answer in treating PFS?

Mark2012 · May 25, 2018, 7:34am

I also thought about this. I wonder are their any drugs that can restart puberty ?

Dubya_B · May 25, 2018, 7:34am

From Wikipedia:

Puberty onset

Puberty is preceded by adrenarche, marking an increase of adrenal androgen production between ages 6-10. Adrenarche is sometimes accompanied by the early appearance of axillary and pubic hair. The first androgenic hair resulting from adrenarche can be also transient and disappear before the onset of true puberty.

The onset of puberty is associated with high GnRH pulsing, which precedes the rise in sex hormones, LH and FSH.[20] Exogenous GnRH pulses cause the onset of puberty.[21] Brain tumors which increase GnRH output may also lead to premature puberty.[22]

The cause of the GnRH rise is unknown. Leptin might be the cause of the GnRH rise. Leptin has receptors in the hypothalamus which synthesizes GnRH.[23] Individuals who are deficient in leptin fail to initiate puberty.[24] The levels of leptin increase with the onset of puberty, and then decline to adult levels when puberty is completed. The rise in GnRH might also be caused by genetics. A study[25] discovered that a mutation in genes encoding both Neurokinin B as well as the Neurokinin B receptor can alter the timing of puberty. The researchers hypothesized that Neurokinin B might play a role in regulating the secretion of Kisspeptin, a compound responsible for triggering direct release of GnRH as well as indirect release of LH and FSH.