Yeah no worries Mew,
Sorry was in a bit of a hurry before, didn’t check the source.
This is one trial on the effectiveness of Horse Chestnut Extract (HSE) in treating chronic veinous insufficiency (CVI):
Horse chestnut seed extract for chronic venous insufficiency.
ncbi.nlm.nih.gov/pubmed/1643 … dinalpos=6
Conservative therapy of chronic venous insufficiency (CVI) consists largely of compression treatment. However, this often causes discomfort and has been associated with poor compliance…One trial indicated that HCSE may be as effective as compression stockings at reducing leg volume. Adverse events were usually mild and infrequent. REVIEWERS’ CONCLUSIONS: The evidence presented implies that HCSE is an efficacious and safe short-term treatment for CVI. However, several caveats exist and more rigorous RCTs are required to assess the efficacy of this treatment option.
More studies:
Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta-analysis of randomized controlled trials and large observational studies.
ncbi.nlm.nih.gov/pubmed/1251 … dinalpos=9
CONCLUSIONS: Based on meta-analyses of RCTs and observational studies, HCSE appears to be an effective and safe treatment for CVI. Further RCTs and carefully conducted large-scale observational studies are required to evaluate the long-term effectiveness and safety of HCSE in routine settings.
Horse-chestnut seed extract for chronic venous insufficiency. A criteria-based systematic review.
ncbi.nlm.nih.gov/pubmed/9828868
CONCLUSIONS: These data imply that HCSE is superior to placebo and as effective as reference medications in alleviating the objective signs and subjective symptoms of CVI. Thus, HCSE represents a treatment option for CVI that is worth considering.
Medical edema protection–clinical benefit in patients with chronic deep vein incompetence. A placebo controlled double blind study.
ncbi.nlm.nih.gov/pubmed/1621440
Treatment with an edema protective agent of the horse chestnut seed extract type is thus a useful adjunct to compression therapy. The tested preparation were well tolerated.
Rational therapy of chronic venous insufficiency – chances and limits of the therapeutic use of horse-chestnut seeds extract
ncbi.nlm.nih.gov/pmc/articles/PMC61039/
Due to its ability to close the venular endothelial gaps, HCSE seems to be a suitable and protecting therapy during the early stages of CVI.