Histone Lysine Methyltransferase Inhibitor (calbiochem)

[Second_Amendment]

This proposal for therapy is based on this post by awor

viewtopic.php?p=24111#p24111

Perhaps the root-root cause of our problem is an overactive Methyltransferase enzyme, which goes about hypermethylating DNA more actively than it should. Proof of this would be an unusual high incidence of cancer cases with persons in our blood line (parents, brother, sister, grandparents, cousins). Does that fit anyone?

There’s a methyltransferase inhibitor marketed by who else? Merck Chemicals. (the German Co. tho, no longer affiliated with the U.S. brand, I believe.

emdchemicals.com/life-science-research/histone-lysine-methyltransferase-inhibitor/EMD_BIO-382190/p_7W2b.s1Oh6kAAAEwFEk7fxos;sid=b5tPy4WST7hby8q5YjginC1S6BhdOwscQ3slbL28DDFJ9ZWObEKy86yVTm9Wj0lCXAFf14ZL6BhdOwIRfWtf14ZL

[Second_Amendment]

Is anyone going to bite on this? This seems promising. It gets to what is highly likely the root cause of PFS. I see a potential problem in that it doesn’t target the right genes. But it gets closer to the problem than any other medication attempted. I’d love to get awor’s thoughts on trying such a therapy. Too bad he’s swamped everytime he logs in.

There’s interesting stuff on methyltransferase inhibitors.

Epimutations, such as the hypermethylation and epigenetic silencing of tumor suppressor genes, play a role in the etiology of human cancers. In contrast to DNA mutations, which are passively inherited through DNA replication, epimutations must be actively maintained because they are reversible. In fact, [Size=4]the reversibility of epimutations by small-molecule inhibitors [/size]provides the foundation for the use of such inhibitors in novel cancer therapy strategies

ncbi.nlm.nih.gov/pubmed/16234563

[Second_Amendment]

And is it USD 149 for just 1 5mg pill?