Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation

Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated BDNF gene expression in rat C6 glioma cells

Progesterone treatment has previously been reported to promote the differentiation of glial cells probably through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated brain-derived neurotrophic factor (BDNF) gene expression, which is considered to contribute to the survival, regeneration, and plasticity of neuronal cells in the brain and hence has been suggested to improve mood disorders and other symptoms in depressive patients. Based on these previous observations, the effects on glial cells of histone deacetylase (HDAC) inhibitors, which are known as agents promoting cell differentiation, were examined using rat C6 glioma cells as a model for in vitro studies. Consequently, trichostatin A (TSA), sodium butyrate (NaB), and valproic acid (VPA) stimulated glial fibrillary acidic protein (GFAP) gene expression, and their stimulatory effects on GFAP gene expression were inhibited by treatment of these cells with finasteride, an inhibitor of the enzyme producing 5alpha-reduced neurosteroids. In addition, HDAC inhibitors enhanced serotonin-stimulated BDNF gene expression, the enhancement of which could be abolished by the inhibition of 5alpha-reduced neurosteroid production in the glioma cells. These results suggest that HDAC inhibitors may be able to promote the differentiation of rat C6 glioma cells through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated BDNF gene expression as a consequence of promoting their differentiation, indicating the possibility that differentiated glial cells may be implicated in preserving the integrity of neural networks as well as improving the function of neuronal cells in the brain.

https://www.researchgate.net/publication/24272351_Histone_deacetylase_inhibitors_promote_neurosteroid-mediated_cell_differentiation_and_enhance_serotonin-stimulated_BDNF_gene_expression_in_rat_C6_glioma_cells

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As a complete novice , what does this mean in terms of what I can try and do. Is there a prescription drug for this or a nootropic ?

I am not a doctor, I can’t recommend anything to anybody. Regarding the post above, there are many histone deacetylase inhibitors (different classes and, of course, different chemicals). There are two
I tried histone deacetylase inhibitors and, in my case, I believe that helped me out the
Sodium butyrate and HBH. My favorite is Sodium Butyrate (SB). You can find it over the counter in Amazon or many other online storages. Some are not legit compounds ( fake SB or HBH mixed with rice powder). The band that I used for SB is Bodybio and I bought it in Amazon and also directly from their website.
HBH you can find it on Amazon or on their website brand BulkSupplements.
In general, I can recommend aerobic exercise ( or running in moderation, you can also do sprint exercises). Stay out of the stress, avoid alcohol, caffeine, and high sugar and smoke.
You can take a hot shower before bed it will help you to relax,