High Adiol-G, what does this mean?

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#1

Hi everybody. A little background. Started working with Dr. Goldstein a few months ago and I have almost trippled my tes but my DHT barely moved up as expected.

My question is. I also got tested for 3alpha-diol G (Androstenediol glucuronide – (“Adiol-G” for short)
and my level is 1504.
On the blood work it states that levels should be from 112-1046 so I am way out of range.
What does it mean to have high Adio G?

I took fin from 30 to 33 with hard core endo crash at 34. I also took avodart from 35 to 38 with another hard core endo crash at 39 and I finally connected the dots a few months ago.

Thank you everybody for making this place for me to get support from. A few months ago I could barely read and write and keep a conversation and I thought I was literally losing my mind, glad I am not the only one and hopefully we will find a cure together.

#2

My 3alpha-Diol G was even higher, with high DHT too. My endo didn’t know how to interpret this.
I know that many PFS sufferers have low DHT and low 3a-Diol G and they are desperately trying to raise it thinking that this is the solution, but this is the proof that raising DHT and its metabolites may not relieve PFS symptoms at all.

#3

in my personal experience, my levels have slowly been rising according to the last endo i spoke with (they run me in and out of there like yesterdays trash so the precise details are sketchy) … however, it brings no genuine improvement, at all … it is like my body just does not recognize it in the same way anymore and the “levels” of the blood are irrelevant, at least in my case

sorry you had to have this happen to you but in reality the situation as a whole is getting better a ton better thanks to the foundation and others who have helped, so just try to remain calm and take care of yourself for now … do not panic

#4

Do we know how many members have high Adiol-g readings?

Until there is a fool proof way to measure 5AR2 enzyme activity we are all fucked.

#5

Raising it isn’t the solution. It’s just a marker for the condition. If your 3 AdiolG is low it seems likely someone has PFS, raising test and 3 adiol g doesn’t fix PFS because the underlying cause is not solved. You are merely treating one symptom of a much more complex condition.

#6

It’s the five alpha reductase type 2 enzyme that we would want to try to raise correct?

The way we measure what are five alpha reductase type 2 enzyme currently is, is besides the point. Now it would make sense that if we managed to raise the enzyme that the test results we now see from the test for the enzyme would also be raised, but are objective is not to raise the marker it’s to raise the enzyme.

I just think that if are theory is, hey these DHT inhibiters messed up are body’s ability to convert testosterone to DHT in places such as the prostate where the 5 alpha reductase type 2 enzyme is present than that’s great but if there is no way to test for this enzyme than there is no way to test this theory.

I have talked to several endo’s about the Adiol-G blood test and not one agreed that that’s a way to test how well or much 5 alpha reductase type 2 enzyme we have working correctly in are prostates or In other places in the body.

So my question is this:
Does The fact that we have at least 2 members saying they have high Adiol-g readings mean that the damaged 5 alpha reductase type 2 enzyme theory is not the answer to are problems?

Or is Adiol-g not even a accurate way to measure what are 5 alpha reductase type 2 enzyme even is?

The fact that doctors don’t even know how to test for this enzyme shows how little doctors even know about this enzyme. Yet they still prescribe medication that attacks it.