Pretty clever…
I took accutane 4 years ago… for about a week or two i was completely impotent… talked to the doctor and he told me it was fine… and for some reason i stayed completely calm, whilst continuing on the drug. the symptoms compeltely turned around one day to 100% of my former self even while still on the drug. I never connected teh dots because the doctor told me this wan’t related. I went on propecia and now I am in this shithole… lawl
Your Endo sounds brilliant ‘Ihatepropecia’ well done, and I hope you recover soon!
Yes, I took both Propecia and Avodart. Took Propecia for years with not really much of a problem, but Avodart messed me up real bad. Lots of the same problems that people with Post-Finasteride Syndrome have. Avodart is WAYYYYY more powerful than Propecia and it has the same chemical effect in the body in terms of blocking the production of DHT.
Any updates here?
Yes, please update.
Anyone can get hold of proviron and arimidex.
Guys, could we please stay on topic. Please discuss theories and recovery strategies in the appropriate sections.
Thanks.
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Dear All, I came here to warn all of you about the most dangerous medicine that I have taken in my entire life - AVODART. I have BPH. I was given Avodart. The medicine destroyed by Penis and my Mind.
I have never felt so depressed ever. the thoughts that go through my mind are so dangerous that I can not describe in words. I have survived because of my wife. Massive depression coupled, with a destroyed penis, has taken away a huge part of my life.
I am an eternal Optimist. An atheist. I know I will survive unless cancer kills me.
Just want to ask around if anybody has managed to recover his penis after getting damaged by Avodart. We will have more discussion as time goes by.
I am sorry to hear. Strangewise, I feel better after I took Avodart for 2 weeks. My condition stems from taking Finasteride (Propecia) for some years. After I took Avodart, I had to wait for 8 to 10 weeks before things improved for me. Have you tried to take Avodart for two weeks and then stopping it? Maybe it will also help to improve your condition. At least from what you write, I don’t think it would make things worse.
Hope you recover.
I think this is really important because I do not see anywhere near the same level of dutasteride problems, and even in studies there is no real discussion of PFS syndrome with dutasteride. Sexual sides are common, but mental sides are not as frequently discussed unless dut is lumped in with fin.
I think there are two primary theories at play for PFS.
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is the so-called “5-ar withdrawal theory”. I’m not positive how it works. It has to do with increased androgen receptivity during finasteride (where there is low DHT), and when DHT comes back “online” after taking the drug, the receptors are flooded with DHT, which sets off a genetic signal to permanently down regulate receptors. The down-stream processes of 3a-hydroxy enzymes are affected.
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the next theory I hear is that the body up-regulates 5-ar1 to compensate for the lack of 5-ar2, and when 5-ar2 comes back online, somehow 5-ar 1 (in the brain) is intensely down-regulated.
Now, if the first theory is true, dutasteride would obviously be terrible because it suppresses DHT even more than finasteride. But if the second theory is true, who knows? Perhaps shutting down both enzymes at once would avoid the sea-saw effect. And sure, you’d still get sexual sides, but taking dutasteride would NOT lead to permanent sides that we see in PFS. That could explain why most of this stuff is around finasteride.
Maybe because dutasteride has such long half life the body is essentialy tappering off by itself and you dont suffer the massive dht flood?
That is a possibility as well. All we know is that dutasteride stays in the body longer at smaller doses, and affects both enzymes.
Accutane and finasteride, both of which are well-known to cause depression, attack only a single isoform of 5-ar.
I came across this thread via search engine, as I was considering starting up dutasteride again for hairloss (tried it briefly in the past, got spooked and stopped).
After reading what I’ve seen here, I think I will pass on trying it again.
I do want to share a method I’ve come across however that I believe works. Look into urine therapy and distilled water. I don’t want to spam the board since I’m a newbie here, however, it’s extremely powerful stuff, especially the former (urine therapy).
I’m quite knowledgeable on the topic so if you have any questions, let me know. The ED and sexual sides from my brief Dut session, as well as long-lingering deep-down depression from my accutane days, both appear to have vanished thanks to UT and/or distilled water.
Urine therapy, as in drinking your own piss?
Yes - there are many books written about it. This is the best/most concise and straightforward I’m aware of:
Drinking wee has cured ED and libido problems? How long where you having side effects and how long where you using Dut? Has anyone else tried this?
lol is this for real?
If 10 people here try it and report that it works, I’ll do it lol
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Not to mention your piss consists of 95% water and 5% waste (which could or could not be toxic on liver). Thats a no for me dog…
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I only did a week of Dut, I stopped because my nipples/“breasts” (lol) were starting to hurt quite a bit, never had that in my life, so got spooked about gyno. I was also getting sexual sides.
I know a week is not much, but I also did 2 full rounds of accutane back in the day, and never fully recovered from the depression for years until learning about urine therapy and distilled water, which eliminated it in fairly short order.
There are several options as far as a protocol goes.
You can simply start drinking a gallon a day of distilled water, and see if anything improves. It may very well help. You have to do it daily though, and indefinitely, at least until your problems are solved.
If you feel that’s not aggressive enough, or not working, add urine therapy to the gallon regimen. After drinking that much water the pee becomes clear, and no longer has a bad tasste - you can literally loop it and it becomes cleaner and clearer each time you drink. Obviously if you have bad diet or eat fast food or something, this throws a bit of a wrench in that and it may taste bad. It actually doesn’t affect the therapy at all though, other than making it taste shitty.
Lastly, the sledgehammer method is simply fasting on nothing but all of your urine, and distilled water if you get thirsty beyond that, for up to thirty days. This is the method described in the book The Water of Life, which I linked in my above reply. This is extremely powerful, but obviously you need free time and dedication.
I realize this all sounds pretty out there, but check out the Armstrong book if you don’t believe me. If you’re more the type who prefers scientific studies/evidence and official case studies rather than anecdotes, you can check out Martha Christie’s “Your Own Perfect Medicine” instead. I just generally share the Armstrong book because it is shorter and much more to the point.
Anyway, my Dut sides cleared up in about a week by doing the distilled water gallons and as much urine therapy as I felt like in the evenings, usually anywhere from one to four glasses or “full bladders,” lol. Again, I swear I’m dead serious with this. As for eliminating the depression from Accutane, it took longer, but less than a year of mainly the distilled water gallons. UT whenever I could, but not totally mandatory in my case.
If you’d rather listen to it be explained instead of read, Andrew Norton Webber breaks it down here (ignore the goofy bumpers for the radio show, the guest Andrew knows his stuff, but there are not many shows that will have a guest on to discuss this subject after all).
Or, Martha Christie below for the scientific breakdown.
