That’s pretty insane we have the same TSH level and high prolactin. I too have low vitamin D and interestingly, double the recommended level of b12. My genetic test predicted that I would have high b12 capabilities and low vitamin D retention.
I have been taking forskolin and I have only had positive effects with it. In terms of our prolactin, we should look at increasing dopamine and/or taking b6 (pyridoxine not pyridoxal).
It is not much conclusive to measure growth hormone levels I recommend Indirect measurement via IGF-1 levels.
And yes mine are also low.
Bro high prolactin induces strong inhibition on erectile function and libido. Fix it as soon as possible.
I also had a little bit too high prolactin (finasteride), vitamin d was 22 ng/mL although it was summer and I was in the sun without sunscreen every day for 2 ours (although I don’t see the link between 5ar inhibitors and vitamin d). The link to GH is easier to explain
Yes, that would be the next step. But if the problem lies in the microbiome disruption (resulting in less arginine reaching the blood) - the stimulation test is probably going yield normal results.
A) Interesting therefore would also be the amino acid values in the blood of patients.
B) Whether high dose arginine supplementation could reduce some of the symptoms fatigue, cognitive problems etc.
Diving into GH deeper. Ther stimulation test is done with Arginine i.v. Which is pretty interesting as some people in this forum described short-term improvements on Arginine (especially brain fog). GH has a protective effect on the brain. Brain fog is most likely caused by neuroinflammation. So it makes perfect sense, that the microbiome dysbiosis in PFS is causing problems in the uptake of certain amino acids and therefore resulting in low GH (which may play a role in some of the neurological symptoms). That arginine supplementation is giving only short-time relief may be due to the little GH increase that takes place under arginine.
I think more research should be done to validate whether GH is somewhat lower in PFS, PSSD patients than in healthy young individuals!
I’ve had two GH and to IGF-1 labs
GH was low then low/mid
IGF-1 was high them mid/high
Did you feel any improvements with GH being higher the second time?
Note: GH is fluctuating. If you had protego-rich meal or exercise before, it’s shooting up a bit
This study compares the b6’s and it states that pyridoxine increases 5AR but pyridoxal inhibits 5AR. Also, pyridoxine seems to increase growth hormone and reduce prolactin better than pyridoxal.
No
I don’t think GH has much to do with PFS tbh.
Agree, sucks he’s still banned Just my thoughts and ongoing hypothesis...continuously changing and in draft mode so please do not take any of this information as a recovery treatment
Mods also haven’t given us a solution for us to contact him. Hope he reads this and lets us know how.
i’m on prescribed growth hormone replacement, so i can tell you a bit about this. these days it’s a real pain to get it prescribed, i had to do a 6 hour test where they hook you up to an iv inject you with glucagon and keep taking your blood. having a low GH value isn’t a big deal, you aren’t really going to see that go up unless you just inject yourself with GH and take the blood within an hour. it’s one of the popular ways that bodybuilders check to see if their gh they order is real. igf1 value is the real indicator which you tested and have a good value, fasting is also another good way to raise it. if you have high prolactin, sometimes you can have a pituitary tumor like i have, but you have good testosterone levels, and the prolactin is just top of range and that can vary a bit. i know you want an answer but the labs look pretty good.
Can you tell us how HGH has impacted your condition, please? In regards to libido, energy, brain/neuro symptoms, muscles, etc.
Thank you!
i was on hgh prior to the pfs, but it hasn’t helped me in any way regardless of dose. to be fair though, in my case nothing has ever helped me. i wouldn’t have even called myself normal before the pfs. lifelong fatigue, depression, anxiety. i had the testosterone of a 90 year old man, low vit d, no hgh, severe sleep apnea, high estrogen. fixing all of that stuff made no difference for me, i even always had thick good hair, but i was doing a bunch of extreme dieting/fasting and my hair was thinning out which was probably just temporary but i tried the finasteride anyway. so now i’m all of the stuff i always was, less hair and now a whole host of problems that fin brought on. life is great.
I see. Thank you so much for explaining. Many of us, including myself, are curious to see how people respond to treatments that are rare or hard to come by.
I have a igf1 high
This is very interested thread also. I think @zzz123 is definitely on the right track. These are the main aspect that we should focus, also on my opinion. Gut and adrenals. But on top of those we should support the body from many different directions in order to archieve any progress.
My labs referring to the original subject:
(These are 8 months after crash) ->
GH: 0.28 ug/l [range 0-3]
IGF1: 54.3 nmol/l [range 11-35]
Prolactin: 287 mU/l [range 86-324]
TSH: 2.0 mU/l [range 0.27-4.2]
So I have highish prolactin but check my B6 and B12 labs ->
(These are 17 months after crash) ->
B6: 338 nmol/l [range 35-110]
B12: 255 pmol/l [range 180-700]
My advice is that before you supplement anything, get tested for the particular parameter.
For example it would be insane for me to supplement any kind of B6.
What comes to the growth hormone, I remembered looking this interesting video at some point ->
Seems like most PFS patients have low GH and high IGF1. That’s interesting.
Yes, I would also not recommend to supplement B6 pills. Recent studies on vitamin supplements showed that they are rather ineffective or associated with shortened lifespan. This association was not true for vitamins naturally occurring in food (so rather eat stuff that contains more B6 than supplementing it). B6 is one of the more harmless or good vitamins. The only thing I found was increased risk of osteoporosis for those supplementing it.
Btw. I took arginine for stimulating GH. I don’t know if it was coincidence, but the first night when I took 2x 1g I woke up with quite hard nocturnal erection. This maybe coincidence though.
I wonder if MK-677 can act like your pharma HGH too?
Studies showed that it increases GH and thus igf-1 to a great degree… i will use it soon.
Btw, did you really feel 100 back on all sexual sides? That’s impressive. Penis hardness and size and orgasms?
Please explain.