HairDX Introduces Genetic Test For Finasteride Response - Androgen Receptor testing

More evidence that Finasteride affects everyone differently based on their genetic makeup and Androgen Receptor CAG repeats. The below company (HairDX) is likely basing their testing on this piece of research: propeciahelp.com/forum/viewtopic.php?t=1406

Note: this sounds like an alternate way to test our Androgen Receptor CAG repeats (mouth swab mailed to their lab). I don’t know how useful or “true” a mouth swab is compared to blood test, however.

According to HairDX, "The HairDX (RxR) Genetic Test for Finasteride Response is available through qualified doctors. – hairdx.com/Doctors.aspx

More info:
hairdx.com/FinasterideTestMale.aspx?view=2
hairdx.com/FinasterideTestMale.aspx
hairdx.com/Science.aspx
hairdx.com/FAQs.aspx


reuters.com/article/pressRel … BW20090309

HairDX Introduces Genetic Test For Finasteride Response
Breakthrough Test Helps Doctors Determine Best Treatment To Save Patients’ Hair

SAN FRANCISCO — Molecular dermatology research and development innovator PharmaGenoma, Inc. and its subsidiary HairDX, LLC (www.hairdx.com), pioneers of genetic tests for predicting the risk of male and female hair loss, today introduced The HairDX (RxR) Genetic Test for Finasteride - a breakthrough genetic test for predicting Finasteride response for the treatment of common hair loss (Androgenetic Alopecia).

The announcement was made at the annual meeting of The American Academy of Dermatology. The HairDX (RxR) Genetic Test for Finasteride is available now and carries a suggested retail price of $199.

Finasteride is the active ingredient in medications used by doctors to help prevent patient hair loss due to Androgenetic Alopecia (AGA). The threat of a sexual side effect often deters patients from using Finasteride because they are uncertain that there will be enough of a benefit to warrant the risk. Others are discouraged by the slow progress of hair growth combined with the cost of Finasteride, and quit the therapy before they see results.

The HairDX (RxR) Genetic Test for Finasteride Response will help doctors predetermine if patients will have a subtle, moderate, or great treatment response to Finasteride, allowing the physician to provide patients with the best treatment regimen to save their hair.

Currently one of the most widely prescribed medications, Finasteride, works by blocking the production of the androgen called DHT (dihydrotestosterone), the hormone responsible for hair loss in Androgenetic Alopecia. For many years Finasteride therapy, which blocks the enzyme 5- alpha reductase from converting testosterone into dihydrotestosterone (DHT), has become a mainstay to treat AGA. This treatment is an effective means to stabilize hair loss, and in some cases to strengthen and re-grow lost hair.

The Androgen Receptor gene has been identified as a major determinant of Androgenetic Alopecia (AGA), commonly called male pattern baldness. Certain variants of the nucleoside sequence on the Androgen Receptor gene, known as CAG repeats, appear to determine androgen sensitivity in men. The HairDX (RxR) Genetic Test for Finasteride Response provides doctors with a patient score, called the CAG repeat score.

A smaller CAG test score is associated with an increased response to Finasteride for treatment of Androgenetic Alopecia,” says Dr. Sharon Keene, HairDX Chief Medical Officer. “Scientists discovered that among men that had the best response to Finasteride approximately 70% had a CAG score below 22 while among men that had a subtle response to Finasteride approximately 70% had a CAG score above 22.”

So has anyone ever tried their service?

This is from the user hopedieslast.

viewtopic.php?f=4&t=3918&p=41843&hilit=cag#p41843

This is from the user pps

viewtopic.php?f=0&t=3757&p=24469&hilit=cag#p24469

So far we have one below 22 and one above 22. Does this suggest pfs has nothing to do with this?

This seems to target how well a prospective user will respond to finasteride with regards to its usefullness but not adverse side effects…am I correct?

One thing to add. As a lawyer, this really blows my mind and I dont understand how this happens. When Merck put out propecia, the clinical trials showed the side effects of testicular pain, rash, erectile dysfunction etc…that presumably disappeared after continued usage (who knows if this is true). Doesnt the FDA require at least some explanantions of WHAT caused the adverse effects? You would think Merck would have to explain the pathology of the adverse side effects before the FDA would approve it. Can I out out a drug that turns you, temporarily into a lizard, but if the effect diminishes within a reasonable amount of time…well thats good enough for the FDA

Excellent point. I wonder about their rationale. Perhaps since these problems only affected a very small minority, a full explanation was not necessary. Or perhaps they figure that further study of this small minority would eventually unearth the answers, and this is just the nature of scientific progress. Either way, it really sucks if you’re one of the poor sods affected.