Hair loss after fin

[cando]

@tim1911

I can count the numbers of hairs i have seen falling out in the last couple of months on one hand, this is at 18 months off for me. I know there are other members who have had slowed/stopped hair loss post fin.

This is very interesting, awor do you have an explaination for this variation?

I guess that although vaguely desirable on the surface, this must be a bad sign, to be honest for me it’s diffcult to tell, it may be that my hairloss has slowed slightly, i mean i’m probably losing fewer hairs as have fewer hairs on my head but it’s progressing at the same rate if that makes sense. Course now every hair that comes out i think “yes! dht!” ironic… I saw a post somewhere the other day about that tingling feeling on the scalp that a person used to get before finasteride (apparently a sign of dht affecting the scalp.) And i realised that i’ve not had it since fin. I don’t think people should write off the importance of the state of hairloss in pfs sufferers, i wouldn;t be surprised if it could tell us something.

[tim1911]

Doing some brief research by contacting members who have had thier 3adiol g tested, thier could be a link between post fin 3adiolg and post fin hairloss status.

Its hard to know though as i could only find 2 members with reasonable 3adiolg readings, and what this would mean if anything who knows, not me.

Maybe anyone who i didnt contact might be able to add something here.

[Oscar]

@awor

@Oscar

On the contrary; Men undergoe full androgen ablation for prostate cancer and there is no evidence they suffer these problems.

Is this your contribution to this site? Just sitting around posting random nonsense all day? Ever heard of the Androgen Deprivation Syndrome Oscar? Are you really computer illiterate or something? Here is a list of symptoms from men undergoing androgen ablation:

• Hot flushes
• Aches & pains in muscles and joints
• Fatigue & feeling weak
• Memory difficulties
• Mood & emotional swings
• Symptomatic anemia (shortness of breath, dizziness, severe weakness)
• Urinary frequency
• Impotence, loss of libido
• Loss of muscle bulk & strength, worse in pectoral, biceps and quadriceps
• Weight gain and fat redistribution
• Chronic fatigue syndrome
• Gynecomastia
• Osteoporosis
• Alzheimer’s-like symptoms
• Increased serum cholesterol & triglyceride levels

Thank for the reply awor. I have bolded your mistakes in red.

‘These problems’, our problems, occur without lowered hormones. As you can see from your list these side effects occur whilst using anti-androgens. There is NO EVIDENCE that they continue afterwards (apart from sexual ones of course). If this was a phenomenon that was already known about there would be no need for these discussions.

So rather than being random nonsense, its a fact that you need to deal with.

@awor

@Oscar

Spot on, apart from the fact that there is no evidence that the human body works in that way!

Wow Oscar, you really did your research man! With just minimal googling, you would have found an almost infinite source of articles stating that androgen ablation causes hypersensitivity of the AR. Yes - Research has consistently shown that reducing activation of the androgen receptor (either by reducing DHT through 5AR inhibition or by AR antagonism through an anti-androgen such as bicalutamide) can lead to androgen receptor hypersensitivity (01) (02) (03) (04) (05). A state of AR hypersensitivity would cause an amplification of the AR signal (06), mainly through HSP90 acetylation (07). This has been found in prostate cancer, non-prostate cancer and animal settings.

Your right it does occur! In prostate cancer.

I wonder why these research papers dont mention normal cells behaving like this? Is there even any evidence of this occuring outside of cancer?

Since men who already have cancer undergo full androgen ablation and dont suffer persistent side effects, the answer must be: ‘no’.

I suppose we could be genetic freaks, like some giant walking tumour, but the evidence just isnt there. Also prostate cancer becomes ‘hypersensitive’ to androgens which is the EXACT OPPOSITE of what has happened to us - the only exception (sometimes) being hair!