Guys, seriously, start using dermacrine sustain

Therapeutic Efforts Supplements & Lifestyle
#1

It is stated that to really get the results out of this you have to use it long-term, so you may need to use it for a few months until you can really get your mojo back, and possibly even bring it to an enhanced state. In my experience, the stuff really does work, and if I can attribute one supplement that has saved my life this would probably be it. I only used it for one month and I have recovered my sexual ability, maybe not fully since I ran out of the stuff, but I have a triple pack of it on the way in the mail. Also the beneficial effects do last even when you stop using it, and steroid users have succesfully used it as PCT before. I can get horny and get hard erections, maybe not to the level that I used to, but I am getting there as I feel better more and more. Why havenā€™t I made a post in the recoveries section yet you may ask? reason for this is because I really want to put my libido to the test and have one succesful coitus session before doing so. Here is a detailed description on the ingredients and effects of dermacrine sustain, I will be making similar posts on the products paravol and Reset AD shortly.

Dermacrine Sustain is positively correlated to improve body composition, increase virility, and improve erectile function by antagonizing estrogens and stimulating the bodyā€™s natural production of testosterone.

Dermacrine Sustain utilizes a higher dose of the proprietary Phyto Aromatase Inhibitor (Phyto AI) complex and does not include the hormone precursors DHEA and pregnenolone. This makes Dermacrine Sustain suitable to cycle with our original Dermacrine, or to be used as a longer-term testosterone support formula. Dermacrine sustain will also induce a more powerful LH & FSH release, therefore providing more powerful stimulation of the bodies own testosterone production from the testis.

The Phyto-AI blend consists of resveratrol, 7,8 benzoflavone and chrysin, which are natural polyphenols that have been proven to be effective anti-estrogens.1,2,23 The action by which our Phyto-AI complex inhibits estrogen, is by binding to the aromatase enzyme (CYP 17) and preventing testosterone and androstenedione from interacting with aromatase and converting to estradiol and estrone.3 Another mechanism in which estrogen is reduced, is resveratrolā€™s ability to decrease production of the actual aromatase enzyme itself 4.

This unique combination effectively and safely limits estrogen production. Thus, estrogen is kept in control to avoid nipple sensitivity, fat depositing and testicular shrinkage. Research with animals show that the ingredients in the Phyto-AI blend help enhance fertility, by eliciting a positive response on the hypothalamus, pituitary, testicular axis (HPTA).5,6 Meaning, the Phyto-AI blend increases lutienizing hormone (LH) and follicle stimulating hormone (FSH) release from the pituitary. As most of you know, these are the hormones sent from the brain that trigger testosterone production and spermatogenesis from the testis. Remember, FSH also sensitizes the testis to the effects of LH by increasing the number of LH receptors in the testis, therefore enhancing testicular sensitivity and increasing the testosterone response.

In the animal study with resveratrol, the LH & FSH levels doubled , while testosterone nearly tripled compared to the control animals.5 Animal studies with chrysin and benzoflavone also noted increased sperm production, increased mounting behavior and a general ā€œaphrodisiacā€ like property from these flavones. This applies to humans as well, since chrysin and 7,8 benzoflavone are the main active constituents of passion flower (passiflora incarnate) which has long been known to posses aphrodisiac like properties and has been prescribed to humans for sexual disorders in other countries.7,8

An interesting effect seen with resveratrol is its ability to antagonize estrogen at the estrogen receptor (ER) by acting as a selective estrogen receptor modulator (SERM) 5,12,13 This partly explains the effects resveratrol has on LH & FSH release. The action can be explained by comparing resveratrol to other SERMā€™s such as clomid & nolvadex. Fortunately, it appears resveratrolā€™s benefit is not associated with the toxic side effects of clomid and nolvadex such as liver stress, DNA damage, reduced sex drive, and reduced fertility. 5,12-22

Aside from simply reducing and antagonizing estrogen, resveratrol has been under intense research for its chemo-preventative effects in breast and prostate cancer.24-27 It also appears that resveratrol has potential for the treatment of metabolic syndrome, by increasing mitochondrial function and insulin sensitivity. 28 In a recent animal study, high doses of resveratrol were able to increase mitochondrial energy expenditure in fat tissue, while increasing mitochondrial concentration in muscle tissue. Thatā€™s right, resveratrol was able to chemically remodel muscle tissue for increased physical output, without exercise. It was well summarized here by M Lagouge et al. -

ā€œresveratrol could hence be viewed as a performance enhancing drug, which, in contrast to other pharmacological mediators, such as anabolic steroids, improves performance by changing myo-fiber specificity rather than increasing muscle massā€

These are exciting implications for the ingredients in Dermacrine Sustain. Weā€™ve included high a concentration of these actives to resemble the dosages used in the virility enhancing clinical studies mentioned above. As a side benefit to the estrogen reducing, testosterone boosting effects, the natural ingredients in Phyto AI have shown to be ā€œvaso-relaxantsā€, which may help promote blood flow to genitalia and support erectile function, while also supporting healthy cardiovascular system.9-11

The ingredients in Dermacrine Sustain are known to be safe, however this product is not intended to be used by anyone under the age of 18, females whom are pregnant or breast feeding, elderly, or anyone diagnosed with a serious health condition including but not limited to cancer, BPH, epilepsy, depression, diabetes, cardiovascular disease or high blood pressure. Always consult your physician before using Dermacrine Sustain with any over-the-counter or prescription medication. Discontinue use if you experience headache, nausea, heart palpitations or skin rash.

Some users may experience acne and an increased appetite, related to increased androgen and testosterone levels. Reducing dosage may alleviate these symptoms. For those wishing to avoid an increase in appetite we also suggest stacking Dermacrine with a dietary supplement designed to suppress appetite.

Dermacrineā€™s topical formula contains ingredients that temporarily increase photosensitivity (3-4hr) and increase chance of sunburn. Therefore, caution is advised for those applying the product immediately before direct sun exposure. Also, be sure to wash hands after application and AVOID product contact with eyeā€™s, mouth and genitals.

REFERENCES

  1. Inhibition of human estrogen synthetase (aromatase) by flavones JT Kellis, Jr and LE Vickery Science, Sep 1984; 225: 1032 - 1034.

  2. The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells Yun Wang, Kai Woo Lee, Franky L. Chan, Shiuan Chen, and Lai K. Leung Toxicol. Sci., Jul 2006; 92: 71 - 77.

  3. The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells. KM Edmunds, AC Holloway, DJ Crankshaw, SK Agarwal, and WG Foster Reprod Nutr Dev, November 1, 2005; 45(6): 709-20.

  4. Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells. S Rice, HD Mason, and SA Whitehead J Steroid Biochem Mol Biol, Nov 2006; 101(4-5): 216-25

  5. trans-Resveratrol, a Natural Antioxidant from Grapes, Increases Sperm Output in Healthy Rats M. Emƭlia Juan, Eulalia GonzƔlez-Pons, Thais Munuera, Joan Ballester, Joan E. Rodrƭguez-Gil, and Joana M. Planas J. Nutr., Apr 2005; 135: 757 - 760

  6. Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Passiflora incarnata Linneaus in healthy male rats. K Dhawan and A Sharma Life Sci, Nov 2002; 71(26): 3059-69.

  7. Lutomski J: Die Bedeutung der Passionsblume in der Heilkunde. Pharmazie in unserer Zeit 1981;10:45-49.

  8. Tyler VE: The Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. Pharmaceutical Products Press, New York , 1993.

  9. Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed. IC Villar, M Galisteo, R Vera, F Oā€™Valle, MF Garcia-Saura, A Zarzuelo, and J Duarte
    J Vasc Res, Nov 2004; 41(6): 509-16.

  10. Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships. OL Woodman, WF Meeker, and M Boujaoude J Cardiovasc Pharmacol, Sep 2005; 46(3): 302-9.

  11. Vasorelaxant effects of grape polyphenols in rat isolated aorta. Possible involvement of a purinergic pathway. Mendes A, Desgranges C, Cheze C, Vercauteren J, and Freslon JL. Fundam Clin Pharmacol 17: 673-681, 2003

  12. Is resveratrol an estrogen agonist in growing rats? Turner, R. T., Evans, G. L., Zhang, M., Maran, A. & Sibonga J. D. Endocrinology 140: 50-54. (1999)

  13. Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats.

Kubo, K., Arai, O., Omura, M., Watanabe, R., Ogata, R. & Aou, S. Neurosci. Res. 45: 345-356. (2003)

  1. Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis. VP Tryndyak, O Kovalchuk, L Muskhelishvili, B Montgomery, R Rodriguez-Juarez, S Melnyk, SA Ross, FA Beland, and IP Pogribny Mol Carcinog, Mar 2007; 46(3): 187-97

  2. Biotransformation of the Antiestrogen Clomiphene to Chemically Reactive Metabolites in the Immature Female Rat Peter C. Ruenitz, Richard F. Arrendale, Garry D. George, Carolyn B. Thompson, Corwin M. Mokler, and Nitin T. Nanavati Cancer Res., Aug 1987; 47: 4015 - 4019.

  3. Antiestrogens and the formation of DNA damage in rats: a comparison. Kim SY, Suzuki N, Laxmi YR, Umemoto A, Matsuda T, Shibutani S. Chem Res Toxicol. 2006 Jun;19(6):852-8.

  4. Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E by uterine peroxidase to form DNA adducts: Comparison with DNA adducts formed in the uterus of Sprague-Dawley rats treated with tamoxifen Deena N. Pathak, Krisztina Pongracz, and William J. Bodell Carcinogenesis, Sep 1996; 17: 1785 - 1790

  5. Activation of the Tamoxifen Derivative Metabolite E to Form DNA Adducts: Comparison with the Adducts Formed by Microsomal Activation of Tamoxifen Krisztina Pongracz, Deena N. Pathak, Takemichi Nakamura, Alma L. Burlingame, and William J. Bodell Cancer Res., Jul 1995; 55: 3012 - 3015.

  6. Teratogenic effects of clomiphene, tamoxifen, and diethylstilbestrol on the developing human female genital tract. GR Cunha, O Taguchi, R Namikawa, Y Nishizuka, and SJ Robboy Hum Pathol, Nov 1987; 18(11): 1132-43.

  7. Effects of tamoxifen on the fertility of male rats MK Gill-Sharma, K Gopalkrishnan, N Balasinor, P Parte, S Jayaraman, and HS Juneja J Reprod Fertil, Nov 1993; 99: 395.

  8. Effect of chronic administration of Tamoxifen on fertility in male bonnet monkeys (Macaca radiata). AJ Rao, SG Ramachandra, V Ramesh, HN Krishnamurthy, S Jayaraman, K Gopalakrishnan, and HS Juneja Andrologia, May 1998; 30(3): 129-32.

  9. Tamoxifen treatment and its consequences Adrian Shulman, Ilan Cohen, Ron Maymon, and Marco M. Altaras Hum. Reprod., Aug 1995; 10: 2174 - 2175

  10. The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells Y. Wang, K. W. Lee, F. L. Chan, S. Chen, and L. K. Leung Toxicol. Sci., July 1, 2006; 92(1): 71 - 77.

  11. Phytoestrogen regulation of a Vitamin D3 receptor promoter and 1,25-dihydroxyvitamin D3 actions in human breast cancer cells. J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):149-57

  12. Potent Inhibitory Effects of Resveratrol Derivatives on Progression of Prostate Cancer Cells. Yoo KM, et al. Arch Pharm (Weinheim) Apr 18;339(5):238-241 (2006)

  13. Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells. Scifo C, et al. Oncol Res. 2004;14 (9) :415-26.

  14. Detoxifying Cancer Causing Agents to Prevent Cancer Margaret Hanausek, Zbigniew Walaszek, and Thomas J. Slaga Integr Cancer Ther, Jun 2003; 2: 139 - 144.

  15. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. M Lagouge, C Argmann, Z Gerhart-Hines, H Meziane, C Lerin, F Daussin, N Messadeq, J Milne, P Lambert, P Elliott, B Geny, M Laakso, P Puigserver, and J Auwerx Cell, Dec 2006; 127 (6) : 1109-22

#2

Well, after reading your post and some follow-up research I decided to give it a shot. So far:

Started applying the Sustain roughly 2 and a 1/2 weeks ago, using four pumps rather than the recommended 5-6. I noticed an immediate boost the first day in mood and energy. I wondered if that was even possible or just a coincidence with some of my regular ups and downs. Looking into other peopleā€™s experiences with transdermals it is quite common, it seems. Libido, decent erections in the morning and maybe the first middle-of-the-night one in who knows how long followed over the next night/day. Anyway, that lasted three or four days.

And then I totally bottomed out for the next ten days. Like as bad as ever, only with that extra strain of having been let down by another treatment idea that seemed hopeful. Felt so shit.

Fastforward to this past Saturday night (5 nights ago): Was stressing about this and couldnā€™t sleep. I try not to visit these sites before turning in because I always get worked up about it, but I wanted to see what the next thing might be and I ordered a bottle of paravol hoping that might float me short-term until the Sustain might have a last chance of kicking in or coming back again (not yet arrived). Went to bed past 3:30 still wide awake. I have a habit of checking out my ā€˜basketā€™ before falling asleep usually to try and notice if there are any changes. Nothing.

Then boom. 4am, like a light switched on, Iā€™m suddenly pretty horny, feel around a little and everything (testes) have totally swollen up (in a good way). Honestly, itā€™s weird ā€“ I never thought a surge would just happen within minutes just like that, but it did. Since then, for the last four days, everythingā€™s been good and steady in every way (my main issues, along with the sexual sides, have been severe spikes of anxiety and depression, and thatā€™s all improved drastically).

Itā€™s now day 19 with the Dermacrine Sustain, and I had already decided after the first week that Iā€™d give it two months before kicking it if it had no effect. Like you Big Softie, I went for the 3-pack special dealie (a no-brainer for me since once everythingā€™s factored in the third ends up being almost free to ship where I am), so I guess itā€™ll be four months.

Anyway, Iā€™m very cautious about getting carried away with being over this nasty spell in my life, but at least these are serious signs for optimistism. This past few days is the best Iā€™ve felt overall since the initial high after quitting fin. At the very least, this stuff clearly ainā€™t snake oil and it is also quite powerful to have, almost in a single stroke, wiped me of any symptoms.

I think there should be a sticky for this, or at least for resveratrol, which appears to be the key ingredient. Oh and a special note for anyone possibly undertaking this is that the Sustain seems to be the choice over original Dermacrine, for reasons that are probably best explained by their site or doing a little research. Something to do with DHEA, which caused side effects like what many of us already experience, but Iā€™m not really sure about why or what since I just skimmed the descriptive text once I realized it was not recommended for someone in my situation.

#3

Hey Iā€™m really happy to hear your progress!

By far dermacrine sustain is the gentlest quasi-PCT thing out there. I feel like no oneā€™s listening to me sometimes when I say that clomid and nolvadex and all that crap have side effects of their ownā€¦ Even if I was going that route I would probably go with a newer version of the aformentioned medications such as Evista, and Dr. Crisler would agree with meā€¦

Also keep in mind, paravol is fairly weak, you might have to double or even triple the dosage for a pronounced effect, though this will kill your wallet. I think thereā€™s another product out there called Diesel Test or something which is more effective, there is also a product called ejaculoid.

1 Like
#4

Hereā€™s a nice link about a forum post on anabolicminds about the effects of SERMs and the difference with sustain. Prescription drug SERMs can have the effects of causing impotence by themselves, and nolvadex can even raise estrogen levels.

This is what Primordial Performance had to say about about Rx SERMs:

Usually, the decision for someone to use Sustain over Clomid or Nolva is to avoid the side-effecs of these SERMs. I personally donā€™t use either clomid or nolva due to there extensive toxic profile. (liver toxic, ocular toxic, genotoxic, libido suppressing, ect)

Clomid and Nolva are synthetic estrogens that have super-estrogen effects, anti-estrogenic effects, and screwy DNA damaging effects depending on the bodily tissue and metabolite. I went through exhaustive research with these compounds, and the closer you look at them, the more damaging they appear.

Consider this ā€“ We are about to enter the 3th major generation of medical SERMS. Clomid and Nolva are first generation SERMā€™s with the worst side effect profile, toremifene and raloxifene are second generation, and bazedoxifene, arzoxifene, and lasofoxifene are 3rd generation. Each generation improves upon the previous generation by being less toxic. That should tell you something. I can post a full referenced write up on this.

Everyone who has replaced their typical SERMs with Sustain has been more than happy. So far, everyone claims to actually be recovering better with Sustain, compared to clomid or nolva. While I do believe Sustain to be equally effective for post cycle therapy purposes, I think peopleā€™s results are so positive because they are simply suffering from less side effects. (Contrary to popular believe, post cycle sexual dysfunction is often a result of PCT drugs such as clomid or nolva, not low testosterone)

-Pp

The bad part is that a lot of the new drugs are still in clinical studies awaiting approval. Evista is available, but very expensive, and I highly doubt youā€™ll be able to buy it off an online pharmacy without a doctorā€™s prescription. If youā€™re at the point where you want to try SERM PCT please do not use clomid or nolva, ask about Evista or even if thereā€™s a possible way to get a hold of the experimental drugs. I believe toremifene (Fareston) is also available by prescription, and is also not available via online pharmacy (you really gotta have a good doctor for this stuff).

#5

Big softie I saw they discontinued dermacrin sustain

Now they have sustain alpha +some other new products.
Sustain alpha contains extra aromatic oils.
Did you try this one?Works as good as the old one?Some insight will be helpful for other if they want to try this one.

I tried grape juice and I can tell you seems to work similar way but Iā€™m not yet sure.

I got too a bottle of sustain alpha but I will not use it yet because I feel very well and also I will do my hormones so Iā€™m not ready to try new thing before I see were I stand.I prefer natural ones because I 'm afraid once I finish it I can get a rebound which seems to be the case of clomid drug.

#6

Sustain Alpha is supposed to be even better than dermacrine sustain. I am looking forward to trying it out after my current batch runs out, along with that new toco-8 product they have which is supposed to work synergistically with sustain and improve cardiovascular health (hell they even claim it grows your hair back).

Not using the product before a blood test would probably be a good idea if you havenā€™t had one done yet. Mewā€™s stated before that itā€™s important to not contaminate your results with any supplements you might be taking so you will have more accurate information on where you are.

I highly recommend the sustain alpha product though, I canā€™t say Iā€™ve tried it myself yet but I really canā€™t wait to.

#7

big softie , how long did you take propecia for?

#8

.

#9

Search his post history for the answers.

#10

I tried to find this stuff at a local healthfood store, but my search turned up nothing. Anyone have any ideas on where I could get Sustain Alpha or Dermacrine Sustain?

#11

you have to buy it online throgh primordial performance

#12

How the hell do you guys get the prescription drugs?

#13

Joe,

You can buy many of these things right on line here in the States. They put so much out on the market so quickly and it takes the regulators so long before they finally find it and squash it, that you can get your hands on almost anything. I donā€™t know if PP ships to the UK, but they are one of the best, IMO

#14

Can someone link me to this product?

ebay.com/itm/BPS-Trans-Derma ā€¦ SwZVlXiR-7

I found this not sure if this is right though. Donā€™t want to spend $80 on the wrong thing.