So again, real simple thought. It could be as simple as what do you knock down and what do you promote? This would be based on the thought of greatly deficient or specific microbes.
Choose wrong and you’ll probably get worse.
Theory, but this might be the closest thing coming down the pipeline as a possibility.
both natural and controlled microbiome composition leads to distinct, and predictable, gene expression profiles in host cells
specific microbes play an important role in regulating expression of individual host genes involved in human complex traits. The ability to fine tune the expression of host genes by manipulating the microbiome suggests future therapeutic routes.