Gut bacteria tied to disease severity, immune response; high mental health toll seen in ICUs

General Discussion
#1

Just replace virus with Accutane, Fin, SSRIs etc.

Gut bacteria tied to COVID-19 severity, immune response

The microscopic organisms living in our intestines may influence the severity of COVID-19 and the body’s immune response to it, and could account for lingering symptoms, researchers reported on Monday in the journal Gut. They found that the gut microorganisms in COVID-19 patients were very different from those in uninfected individuals. “COVID patients lack certain good bacteria known to regulate our immune system,” said Dr. Siew Ng of The Chinese University of Hong Kong. The presence of an abnormal assortment of gut bacteria, or “dysbiosis,” persists after the virus is gone and could play a role in the long-lasting symptoms that plague some patients, she said.

On a side note, I think you absolutely need to be able to generate heat, whether thats the brain, head, skin, eyes, penis, gum tissue.
Those feeling some type of unusual coldness or even drop in body temp could be in the most trouble possibly.

2 Likes
#2

So FMT might work on some cases if this would be one of the keys?

#3

They are not even sure why FMT work in some and not in others when it comes to treatment of C.diff for example. Its the same with probiotics, its too non-specific. Take the (s) off of probiotics. Believe me there are plenty of bacteria that you dont want, that could make your situation worse. In that regard FMT does not make sense to me.
It would need to be a targeted approach and you need to know the specific characteristic or traits of select bacteria.
In regards to this and the article above, this is what im looking at right now.
A specific trait could be retinoic acid metabolism that could help regulate the immune system.

Portrait of an immunoregulatory bifidobacterium

#4

I’ll add to this, also what about tryptophan metabolism?

Role for Metabolic Factors in Probiotic-Mediated Immunoregulation

Konieczna et al. demonstrate that induction of vitamin A and tryptophan metabolic pathways in DCs by B. infantis is important for adaptive immune cell responses.13 These metabolic pathways are recognized participants in immunoregulatory mechanisms. That food-grade microbes deploy these mechanisms raises the possibility of a new link between diet, microbiota, metabolism and immunoregulation. Simply put, B. infantis administration to an individual, with a diet deficient in vitamin A and/or tryptophan, may not be as effective as B. infantis administration to an individual with a diet incorporating sufficient quantities of these nutrients. At present this is a hypothesis, however recent findings regarding other dietary factors support that certain dietary factors may be important for microbiota and probiotic-associated immunoregulation.35 For example, microbial fermentation of dietary oligosaccharides results in short chain fatty acid secretion and immunoregulation via GPCR41 and GPCR43.36

#5

A few more articles here.
For the first one Im looking at Vitamin A status or even possible metabolism going hand in hand with bifido abundance.
Could bifido abundance promote dietary vitamin a metabolism?
This would be select strains.
Neonatal Vitamin A Supplementation and
Vitamin A Status Are Associated with Gut
Microbiome Composition in Bangladeshi
Infants in Early Infancy and at 2 Years of Age

In conclusion, VA supplementation was associated with
a higher relative abundance of Bifidobacterium and better
VA status was associated with higher abundance of another
mucosa-associated genus, Akkermansia. Given the role of
VA in promoting intestinal immunity and epithelial integrity,
as discussed above, VA appears to also promote healthy
colonization of the intestinal mucosa with commensal bacteria,
a role that has not been previously appreciated. Increasing
the abundance of Bifidobacterium may modulate immune
development to promote health in infancy as well as later in life,
including the promotion of more robust vaccine responses

we suggest that studies focused on the impact of dietary factors and microbiota-associated molecular pathways should be a priority, so that preventive and therapeutic strategies may be formulated by matching essential microbes with dietary components. It remains to be shown whether the B. infantis immunoregulatory responses described in healthy human volunteers will also be observed in patients with inflammatory disorders. The data are encouraging and call for the further evaluation of this microbe in patients.

The probiotic Bifidobacterium in the management of Coronavirus: A theoretical basis

https://journals.sagepub.com/doi/full/10.1177/2058738420961304

#6

More than 92 million people worldwide have tested positive for SARS-CoV-2, the virus that causes COVID-19, and a little more than half of these people have recovered so far.

However, recovering from COVID-19 does not mean that a person’s experience with the virus is over. Research indicates that around 32% of people experience long-term health effects from COVID-19, which scientists have dubbed “long COVID.”

A new paper that appears in the journal Gut suggests that the composition of the gut microbiome at the time of infection may impact whether someone experiences long COVID.

The paper also concludes that gut bacteria may affect the severity of the symptoms during the infection.

You dont have to have a degree in microbiology to realize some of these same thoughts or principles could apply to drugs and supplements.
It makes sense as to how symptoms could come on rapidly and become ongoing.

The complex relationship between drugs and the microbiome

https://www.nature.com/articles/d41586-020-00196-0

Scientists know that the microbiome has an effect on pharmaceuticals, and vice versa, but they are still trying to work out the various mechanisms involved.