GSK funded study on 5ARI's effects on bone mineral density, sexual behaviour, PSA, etc

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#1

Not sure if this has been posted before. Seems like a long(er) tern study with a follow up.

ncbi.nlm.nih.gov/pmc/articles/PMC2684818/

The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen and Sexual Function in Healthy Young Men

Results
Significant suppression of circulating dihydrotestosterone levels with the administration of dutasteride or finasteride did not significantly affect bone mineral density or markers of bone metabolism. Similarly serum lipoproteins and hemoglobin were unaffected. Serum prostate specific antigen and self-assessed sexual function decreased slightly during treatment with both 5α-reductase inhibitors but returned to baseline during followup.

Conclusions
Profound suppression of circulating serum dihydrotestosterone induced by 5α-reductase inhibitors during 1 year does not adversely impact bone, serum lipoproteins or hemoglobin, and has a minimal, reversible effect on serum prostate specific antigen and sexual function in normal men. Circulating dihydrotestosterone does not appear to have a clinically significant role in modulating bone mass, hematopoiesis or lipid metabolism in normal men.

#2

No offense but the results of this study are crap. Fin sufferers have low T an low Vitamin D but of which have long term negative impacts on bones and bone density. We (fin sufferers) are at a vastly increased risk later in life for bone problems.

#3

jcem.endojournals.org/cgi/conten … 87/12/5401

Evidence that our bone mineral density and eventual height (if still growing) would probably not have been affected by taking Propecia.

I’m aware that Sennex took fin from age 15 and is a good height.

JN

#4

But penile growth?

I am only 18.

#5

But what about Propecia affecting the growth hormones? IGF1?