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solonjk,
There is a doctor in the States doing pulsatile GnRH supplementation for secondary hypogonadism. His last name is Crowley and he is in the Boston area, U Mass General. Uses a device about the size of a deck of cards that you wear for weeks at a time on a belt around your abdomen, gives you a GnRH injection subcutaneously every 20 minutes or something like that. He reports something like a 20% restart rate (hypothalmus picks up the secretion pattern and continues after the GnRH pump is removed)… Typically only treats severe secondary hypogonadism (T <100 or 150) in this fashion, but if you’ve got the coin . . . .
As to what my doc thinks, I have not yet been to see him with the result but will in the next couple of weeks. Am hoping he will retest me now that I have T back up to 700 on clomiphene. Come to think of it, that lends credence to your theory - clomiphene as a way to get GnRH going again even in the absence of 5AR2 regulated secretion of GnRH… Would like to read about the 5AR2 vs GnRH thing, in return I will link up some of Crowley’s studies.
kazman
propeciahelp.com/forum/viewt … light=gnrh
This is somewhat interesting, although it’s in rats and relates to GnRH-induced Ca2+ regulation.
propeciahelp.com/forum/viewtopic.php?t=171
Nitric Oxide connection?
propeciahelp.com/forum/viewt … light=gnrh
GABA-A connection?
propeciahelp.com/forum/viewt … light=gnrh
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