Glycine STRONGLY upregulates 5ar activity

Therapeutic Efforts Supplements & Lifestyle
#13

The increase in allopregnanolone synthesis from activation of glycine receptors appears to differ from the way fluoxetine and other SSRIs increase allopregnanolone.

There have been studies posted on this site showing that SSRIs drastically increase allopregnaolone and adiol-g concentrations at the expense of DHP and DHT. (5-ar activity can’t compensate for the increased 3a-HSD activity caused by SSRIs). The resulting DHT deficiency has been speculated to trigger PSSD (Post-SSRI Sexual Dysfunction), in a similar manner as 5-ar inhibition may cause PFS. Either way, you end up with cells that are starved of DHT and other 5-ar metabolites. Not good.
Fairly certain Prof. Melcagni’s neurosteroid study discovered very low levels of DHP in the cerebrospinal fluid of PFS patients.

Another study on glycine receptor agonists where increase of 3a-HSD activity was observed without a decrease in 5-ar metabolites:

V. C, B. N, M.-N. Ag, and P.-M. C, “Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System., Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System,” Evid Based Complement Alternat Med, vol. 2011, 2011, pp. 407617–407617, 2011.
http://europepmc.org/articles/pmc3136435

So, perhaps glycine and gelsemine are ideal treatments to try out considering they may increase allopregnanolone and don’t appear to decrease DHP at the same time.

#14

seems like we need our immune system to accept dht again.

i took dht gel 5g a day and it shrank my dick…

i wonder of megadoses would force your body to accept it.

People say “our 5ar is fine” because our dht is in normal range. But if 5ar was fine allopreg wouldn’t be fucked up lol…

looking forward for people’s results with glycine. …

#15

What about high dose triptorelin like they did in this study? (200 mcg everyday for 3 days)
researchgate.net/profile/Br … 000000.pdf

I want to try it but I’m afraid it could fuck me up even further.

#16

I ordered the glycin and will receive it in about 10 days. More people should be trying this I think, it’s one of the safer treatments that has a potential to work.

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#17

glycine is the supplement i reordered most times.

when it works it works well, for my sleep. problem is i can’t get it to work consistently for my sleep and when it doesn’t work it is actually detrimental. however i take it in 3g dosages.

i’d be curious to see the results on this

#18

I’ve had a 100 mcg triptorelin injection 5 days ago, and started using 16 g glycine and 3 g taurine daily yesterday. I’ll let you know if I feel any different.

#19

keep us updated on glycine

#20

How can you be taking 16 g of glycine a day? Don’t the pills come in 500 mg, which would mean you are taking 32 pills per day??

walmart.com/ip/Glycine-500mg … s/31345339

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#21

The ones I got are 1000 mg capsules. I take 16 capsules a day, 8 in the afternoon and 8 before I go to bed.

#22

Wow, seems like alot ! Any improvements?

#23

Well, I feel slightly stronger at gym, and today it was a bit easier to get an erection while watching porn. Other than that I’m pretty much the same, it’s still a bit early though, as I said I had a triptorelin injection 10 days ago, and it takes about 3 weeks for hormones to peak after injection so my testosterone is probably low right now. I’ll keep you updated if I feel better after a while.

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#24

Thanks for the update.

#25

I’m getting a new blood test on monday, sexually I still feel the same. In general the only difference I notice is the sweat from my armpits smell awful, I don’t remember it smelling this bad since puberty. Hopefully that’s a good sign :stuck_out_tongue: . Edit: I forgot to take into account that I’ve been taking garlic pills for a few weeks now so maybe that’s what makes my sweat stink.

#26

Looking forward your report.

#27

So I’ve been taking taking this for almost 2 months now and my condition remains the same…

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#28

Anyone finding success with glycine, especially for sleep maintenance?

#29

You need both 5ar AND 3a-HSD to make Allopregnanolone.

#30

Nah, this does absolutely nothing. I can’t even take more than 500 mg without getting horrible headaches. Tried dimethylglycine as well as gelatin too. Nothing. Just another ‘paper-cure’ - can’t remember the number of things that supposedly do something in vitro or in rats, yet carry none of those results over into the real world. Next!

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#32

Took a little over 3g a few hours before bed. I woke up after only 2 hours of sleep or less. It made me worse. More than 3 hours later and I still can’t go back to sleep.

#33

Glycine never worked for me and I took up to 6 grams a night.