GHRP-6

Therapeutic Efforts Pharmaceutical
#1

What are your thougths about this? This is what Dr Crisler prescribed me, in order to increase my GH level. I am going to take 100 mcgs before going to bed, every night.

"by Anthony Roberts - GHRP-6 is a peptide in the growth factor family. It has strong effect on the release of Growth Hormone (GH). Its main use is to promote food intake by stimulating hunger and aid in energy metabolism. It can be used in the treatment of GH deficiency as well as cachexia, eating disorders and obesity.

Background

Although still relatively new, peptides have recently become popular as performance enhancing drugs. GHRP-6 is currently available from a few research companies.

Action

The major side effect accompanied by the use of GHRP-6 is a significant increase in appetite due to a stimulating the release of Ghrelin, a peptide which is released naturally in the lining of the stomach and increases hunger and gastric emptying.

GHRP-6 causes stimulation of the anterior pituitary gland which ultimately causes an increase in GH release. Since GHRP-6 acts directly on the feedback loop which signals the inhibition of GH release, when natural GH secretion has been inhibited by long term synthetic use, GHRP-6 can be used to re-stimulate the natural production of GH. GHRP-6 also affects the central nervous system, by protecting neurons as well as increasing strength in a way very similar to the way certain steroids in the Dihydrotestosterone family do.

mesomorphosis.com/steroid-pr … ghrp-6.htm

#2

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#3

Correiovip,

It seems to me anything that stimulates the Pituitary gland would be good idea for us. This seems to be going to the source of the problem rather than slaping a band aid on it with TRT. Did he mention having success prescribing GHRP-6 to other propecia sufferers?

Please keep us posted on how you feel once you begin taking this. This would be fantastic if you got some positive results from the GHRP-6., considering how ridiculously expensive it is to take GH. I really hope it works for you.

#4

So the difference between this and say HRT is that this is is something that stimulates the body to produce it’s own GH as opposed to direct supplementation which would result in further depression of your natural production?

I believe that these are the sort of treatments that fin sufferers need. The thing that separates us from regular HRT candidates is that our bodies are not worn out and unable to produce our own hormones, it’s just that somewhere inside the delicate balance has been scrambled. I’m sure most of the people on this forum are in great physical shape, and that’s what is so fucking frustrating.

I honestly believe we can fix ourselves, at the very least back to 90%, because we have all the tools its just our bodies have forgotten how to use them properly. If our bodies were a herd of sheep then finasteride is the wolf that ate the shepherd and now the flock is out of control. Or maybe i’m oversimplifying i don’t know.

#5

bostonusa,

He’s never prescribed this to a propecia sufferer before, but he has 200 anti-aging patients on it with good results and no side effects.

Mariobros,

You re right, this stimulates the body production of GH.

Thanks!

#6

Hey.

I have stopped taking HGH now. Whilst it improved all aspects of my suffering (improved sexual performance, general well being, stamina), it’s lack clearly wasn’t the underlying problem. Also, I have noticed a more prominent supra-orbital ridge as I was taking too much for too long.

Taking say, 1 unit per day would not cause side-effects of acromegalic proportions, but I was taking 3 units per day, in desperation.

I believe low intracellular DHT metabolism is key, and our low Adiol G is a key common theme.

Not to discredit Crisler (who did not help me much when I was his patient). I wonder about his practice. He never recommended Proviron to me (which he would have known all about given he was a steroid user for 10 years and a bodybuilder)…he goes by SWALE on the bodybuilding forums.

I should hope he is aware of the Adiol G finding.

Proviron and Drostanolone (Masteron) are illegal in USA and I think he’d rather to stick to the rules.

I guess one can see this problem in different ways; I wouldn’t call TRT a band aid. I’d call it a means to get on with life. I can’t see a ‘cure’ for the permanent damage finasteride caused (ie, gene therapy to increase Type 2 activity in cells), so I think injections for life is necessary.

Again, I find bodybuilders much more helpful (and capable!) of solving my issues than doctors who tend not to get involved in what is a medical rarity and stretches their practice such that they feel uncomfortable/don’t have time/simply don’t care.

I spoke to the head of Andrology Australia and he was unaware of an injectable DHT. Bodybuilders have been using Masteron for years! It really pisses me off the way ‘respected’ doctors use T cream. I mean, I feel that is amateur. Needles are clean, less messy, more precise doses etc.

Having suffered for nearly 9 years and even being a doc myself, I find doctors to be massively lacking in their ability to treat us.

I wonder if my low IGF 1 was due to DHT deficiency (it has an effect on the liver to induce formation of IGF 1), rather than low GH production.

See literature below

sciencedirect.com/science?_o … 1a0bd32bb8

#7

Correiovip…I would also like to ask if you know your GH level to be deficient? The only means to check this is by doing an insulin tolerance test (ITT). Just because one is low in IGF 1 doesn’t mean low GH production. (see attached article above).

Surely being deficient in one or more T/DHT may cause low IGF1. I think this may have been true for me. I never had an ITT, but I should have done. (I had just moved to Australia and was not under care of a doc. It’s also an unpleasant test where one glucose levels are lowered to below 2 for 2 hours).

Has Crisler performed an ITT on you?

You may notice good results with GH stimulator, but is it addressing the underlying problem? If GH release from ant pit is normal, why not start DHT injections with a confirmed low Adiol G level?

I am hoping that DHT injections will raise my IGF 1 level by it’s effect on the liver.

Take care

#8

You make a good point,

Does anyone else think it’s strange that no doctors seem to be attempting to find and treat the actual root of the problem? It seems like they’re addressing the individual symptoms. “oh you have low T, so we’ll give you some clomid” or whatever.

Have any of the doctors even been to this forum and read through the research to try and make a theory about why this is happening? I think the reality of the situation is maybe it’s a case of too complex an illness/too few sufferers = not worth the time. I have to say this whole experience has completely shaken my faith in doctors. Why can’t Crisler just take one hour out of his day to come on here and at least give us some ideas about what he thinks in regards to the articles and ideas that Mew and the other guys have put forward, or at least give us some hope that he’s making progress with patients.

I remember once when i was 16, i broke my right elbow playing rugby. i knew it was broken because i could move a bone fragment around under the skin. When i went to the hospital they sent me for an X-Ray and came back and said that everything was fine and i just probably sprained it. So i showed them where the piece of bone was jutting into my skin. “oh” they said “that shouldn’t be there”.

You know what these medical marvels did then? They sent me for an X-Ray of my good arm so they could play “spot the difference” with the two and that’s how they knew something was wrong. Fucking amatuers.

The thing that really makes me angry at myself is if i hadn’t been prescribed propecia by a doctor i probably would have researched it alot more thouroughly and decided against it.

I also think it’s going to be us who gets ourselves fixed because we are the only ones who seem to really give a shit about what happens to us. The truth is that no doctor is going to put in the time needed to come up with a cure, unless they stumble across it through trial and error or dumb luck. we’re going to have to do it ourselves.

#9

regarding the doctors,

mariobros - i guess we all have pretty much the same experiences with doctors.
in fact, they have no fucking clue, don’t care or don’t admit they have no clue and say it is all in your head - ah right - thank your time asshole… .
Ok, anyways, I recently indeed found a urologist (hmm maybe the 10th?) who is pretty much interested in my case, believes everything I say and is willing to take blood tests according to what kind of information I can get from this forum. Meaning - medical awareness is a matter of time and will come 100% sure!
My dermatologist here, who has whatever 15-20 on propecia did not know anything about the side effects people experience and just knows the studies from merck (which i also know). WTF? Quote:“You know I have paients here tkaing that stuff for 10 years now, not one of them ever complained about my issues.” Thanks for the info man, I am not crazy, my mind is sharp - however my dick is not since propecia bullshit.
We have to pull ourselves out of this shit - I agree. But this is not possible without testings done by doctors and as I said a few are there already taking our symptoms very serious - though they don’t have an answer to it…yet.
My respect for doctors also has rapidly declined due to the some experiences, but some are willing and capable, just takes along time to find them.

Take care

#10

sufferer2001,

Thanks for the reply. I know an ITT is what is recommended to check for Gh deficiency. Dr. Crisler wanted me to have an ITT but i refused. I am afraid of that test as i have had bad reactions simply from fasting (which also points to gh deficiency). Any time i tried to lose weight or fast the stress level become unberable and i had to eat something. I am not reacting well to hypoglicemia. Also, i explained to him other symptoms that point to gh deficiency and he agrees.
I know that by using GHRP-6 i will not be addressing the underlying problem, but rather usind a band-aid drug. The problem is we do not have the solution to the main problem yet, i think it is valid to find temporary solutions as long as they are safe. We have no proof that dht injections are safe and that they would fix our problems, though i agree the cause of the problem lies on dht/5arII/adiol G.
There is another aspect of using ghrp-6 that might be beneficial to me. It might help “re-start” adrenals when combined with hydrocortisone. Read the following study:
cat.inist.fr/?aModele=afficheN&cpsidt=14691086

I am not yet sure however for how long i will try this and the dosage. I am still studying and i might not take any of these if i come to the conclusion it is not safe.

#11

UPDATE:

I decided not to take this and try Phosphatidylserine instead since it is a 5 alpha stimulator. I am not going to take the Hydrocortisone eighter.

#12

Keep us updated on this, my Step mothe is a scientist at a prominent hospital in MD and I am going to see my first endo soon and anything will help. My Stepmother want to put me on some kind of drug that shocks the pituitary into producing the right hormones… I’ll get the name from her later and run it by you.

#13

Thank you ScaredinMD

Could you talk to hear about Phospholipids? Read the thread “phosphatidylserine” and please show the researchs to her. Being a scientist, maybe she could shed some light about dosage and what form of administration would be more efficient. My 3 adiol-G is 2.40 (range 3.4 - 22), so it is clear to me i have some kind of 5 alpha reductase deficiency. Have you ever tested 3 adiol G?

#14

I haven’t had any test done yet.
I see my doctor Thursday and I see a new Endo soon.
I will speak to her though.
I’m going to do everything in my power to get over this, and my family is going to, too. In the meantime are you taking a DHEA supplement?

#15

correiovip - Did you try the GHRP-6 at all? Is it a pill or an injectable? The reason I ask is since it was prescribed by a doctor, and he would be monitoring your progress (possibly?), it seems like that might be a preferable path to trying something from the internet (which the path I have been on primarily).

#16

ScaredinMD, make sure you get your Androstenadiol Glucoronide tested (3 adiol G). It is a good marker for 5 ar activity, and dht testing is not.

Badluck,

The reason i decided not to take Ghrp-6 (injectable) anymore is that it would not hit the source of my problems which i believe to be related to 5 ar activity. I researched GHRP-6 and it appears that the effect of this on glucose is unknown in the long run, so it could cause diabetes. Plus, i don’t want to mess with my pituitary, it seems my Pituitary-adrenals axis is already messed up, i got the feeling i could create more imbalance if take something that acts at pituitary without working on 5 alpha reductase beforehand.
Dr. Crisler does not have any experience with GHRP-6 on propecia sufferers, i would be the first. I realized this is too risky.

#17

correiovip,

While I agree that taking an injectable should be left for last, one of my docs told me that increasing GH levels help to upregulate androgen receptors. I am still going through the AR receptor downregulation thread, but it would seem Crisler’s prescription is reasonably well thought out for this reason. As GH levels increase so does IGF-1, and Mew has posted at least one artilce indicating higher IGF-1 strongly favors 5AR2 secretion so good stuff for us I would think…

I have been having pretty good luck (return of nocturnal emisions, 70% increase in IGF-1) using a arginine based GH secrtagogue, though I am off cycle now (must be cycled, and am going to get more GH related testing done so need to be off of it). Taking GH itself is suppressive to the pituitary so thinks like (well made) secretagogues or peptides that increase secretion would seem to be a better way to go.

If you do try the GHRP-6 I would urge you to get IGF-1 tested as a basline, and then test it again after 6 weeks or so on this peptide. I got adiol-G tested at the end of my secretagogue cycle but do not have the numbers yet.

kazman

#18

I did? Where? Perhaps you are confusing me with Suffer2001’s HGH thread in Recoveries section…

#19

Sorry Mew it was not you:

propeciahelp.com/forum/viewt … light=igf1

#20

Thanks kazman,

But i am taking a break. My adrenals seem to be improving ( i believe Phosphatidylserine helped) and i don’t want to waste the gain in well being i have achieved by trying another med.