GHB (Gamma Hydroxy Butyrate)

Therapeutic Efforts Pharmaceutical
#134

I assume you haven’t bothered to click on any of the links i posted then? have you done any of your own research?

kirlian.org/life_enhancement_products/bstc1~1.htm

old.disinfo.com/archive/pages/dossier/id137/pg1/index.html

drugs-forum.com/forum/showthread.php?t=25153

It’s fairly obvious that not everyone would have the same reaction to GHB - PFS or no PFS. However GHB potentially…

. improves sleep
. boosts sex drive
. reduces anxiety
. increases GABA and growth hormone release

That’s just the basic stuff that i can take away from 3 minutes of reading

I would say with 100% certainty that GHB could be very useful to us given it’s potential effects. The benefit of 6-10 hours continuous sleep ALONE would be a huge boost to many PFS victims health so how on earth have you concluded that GHB is useless?

Italysideffect and ithappens improved using GHB

Forget getting GHB (Xyrem) through a doctor, unless you have epilepsy. You either need to buy straight GHB from a drug dealer or buy GBL from the internet and take that or you could convert the GBL to GHB yourself.

#135

"The sleep of narcoleptics is abnormal and characterized by: a short sleep latency; frequent sleep onset REM periods (i.e., REM sleep begins within 30 minutes of going to sleep); REM period interrupted by arousals; higher than normal amount of time spent in stage 1 but less than normal amount spent in slow wave sleep; and frequent arousals from sleep. This results in the patient suffering regularly from very poor quality sleep which can lead to many cataplexy attacks during the day despite the use of prescribed stimulants.

Their brain is simply exhausted and is unable to recover or repair during the night as the patient cannot maintain quality slow wave sleep.

GHB counteracts these abnormalities by increasing slow wave sleep, lessening stage 1 sleep, and reducing arousals from rapid eye movement (REM) sleep.

Simply put, they spend less time in “shallow” sleep and more time in the reparative slow-wave sleep stages (“Deep” sleep).

One similarity in an otherwise healthy person is the parent of a new-born baby. They will likely experience a similar state of regularly interrupted sleep which reduces their ability to reach and maintain the slow-wave stages which can lead to extreme states of mental exhaustion during the day. Although at least they will, eventually, recover as soon as junior can sleep through the night regularly!

In fact, as a quick asides, there are many, many, physiological problems that are the direct result of a poor night’s sleep. Even though a person may be unaware of the poor quality sleep they are frequently experiencing, stress, worry, environmental factors (excessive noise, light etc.) and drug abuse can easily result in a night’s sleep consisting of bouncing between stage one and REM sleep without properly reaching the reparative stages.

After a length of time, there can be serious implications for the person who is frequently unable to reach and maintain quality slow-wave sleep."

Do i need to say more? i am CONSTANTLY dreaming and when i wake up i am often not tired, as if i never fell into a deep sleep.

#136

I’m in contact with a sleep centre that prescribes Xyrem (GHB), my GP referred me.

The ironic thing is, apart from last night where i only slepts 3 hrs, my sleep has been very good and also refreshing for about 5 days - this has also lead me to a pretty healthy recovery in mental and physical symptoms to a point where i would say i’m currently recovered on mental and physical front, sexual is lagging but improving. It’s better when sleep is better, this points towards GABA for me. GHB might just be the thing to solve it. Looks very hard to get Xyrem in the UK, either on private or NHS. I think only 400 people in a poplation of 66m are on it here.

#137

I have this now too. I can tell you it’s better than waking up feeling like shit every day.

#138

It is yes. I am just stating this because it shows how useful GHB could be for us.

It’s great that you have gotten so far with the sleep centre but i very much doubt they will prescribe Xyrem.

#139

Bluecloud, you have very much doubted alot of things on this forum! Rule it all out and you’ll never get anywhere, just like plenty of others who are all still here years later…

Anyway, I have already discussed this with the sleep centre and it’s not out of the question, even without narcolopsy, but it’s a long process getting funding from NHS PCT’s. For that reason sleep centres and docs steer away from it. Of course there are other reasons, but my gut feel is from speaking to them that they basically never bother because it’s rediculously expensive and the cases always flop. I have a very good GP (female + young + hot) and I am hoping she will go the extra mile for me. We’ll see. At the very least they’ll give me some tips (or other medication) to help me sleep better. Since better sleep correlates with improvement for me I’ll take anything that works this angle.

#140

Hi Chi,
I am also booked with a sleep specialist and try to get GHB. I am not so sure of other medications that are given for insomnia. Many of them counteract the sexual problems. I was prescribed one by a doctor and when I bought it and read the leaflet it said that side effects include ED etc. So be careful. I know good sleep is very important, but I am afraid of the side effects of some of those medications.

#141

Thanks Keepup, i’ll look out for this.

Can i just add one comment while we’re on Dr’s…

If yours is old + fat + male, probably worth ditching them for a young + slim + female

Sound rediculous? Not at all.

A fat old man sitting on his chair seeing old ladies all day is about as inspirational as a spoon. If they can’t keep their own body in shape (noting that they have no androgen, prostate, mental or other problems) then how are they going to fix somebody elses, who basically has shit loads of problems that they literally understand nothing about, nor can they be bothered. Also, the very fact that they are male make them much more self centered, selfish and less caring about others. They are more interested in personal gain. The older they are, the less modern knowledge they have and the less able and interested in researching our problem they are.

I’ve had 2 male GPs of this kind since this problem and this is my experience.

Women on the other hand are much more maternal, caring and outwardley thinking. They have emotional attachments to situations and display more sympathy. The younger the better, fresh graduates will be MUCH more opened minded about our problem. They’ll probably research it independantly too. If they are slim, they are more concerned about the health of the human body, may even know of someone that has had health problems and want to optimise theirs. If their in control of their own, they are better placed to be in control, understand and help others. I rate my female GP very highly, she reacts fast to my situation as it changes, is willing to think outside the box and sometimes acts on impetus or gut feel instead of boring (outdated) facts that she has access too. I like this approach, because ultimately, the answer to this problem isn’t recorded anywhere just yet, that’s what Awor is working on with scientists.

My first male GP read off the Propecia leaflet to me and said it was impossible i could have a problem because side effects resolve upon discontinuation of the drug. Thanks, but no thanks, cock.

#142

Hi Chi,
Am in the process of trying to get Xyrem from my Doc in London he is very supportive as he has seen men in the same situation as mine, maybe not as persistent in there demands as me, but you get no where fast in this country. I have an appointment to see him soon and hopefully he will agree to prescribe it to me. I will let you know.

#143

is anyone actively trying to get this in the usa

#144

What the hell are you talking about? i just made a fairly long post about why GHB could be useful for us. The last thing i am doing is ruling it out.

I am saying that it’s unlikely anyone will get Xyrem in the UK because that’s a fact. Do you know how much that drug costs the NHS and the legal stuff they have to go through because of the nature of the drug? trust me, i will be ecstatic if you or Gazza get it but it’s unlikely.

Either way you have taken what i said the completely wrong way. I desperately want at least 1 of us on here to get some GHB soon.

The doctor advice sounds great by the way. I might give a female doctor a go.

#145

I’m going to talk to one of my doctors about GHB/Xyrem. If he perscribes it for me I’ll let you know. Personally, I don’t think it will cure my varient of PFS but I would hope it might give me some improvement in sleep, weight managment, fatigue, depression, etc.

Personally I don’t feel as comfortable talking with a female about my side effects, particularly shrinkage and other sexual sides. I find having those discussions with females, doctor or not, particularly depressing.

@bluecloud- You may want to change your tone a bit with some of us on the forum. Alot of us here are finding it tiresome. At least you’ve refrained from using the annoying emoticons in your last few posts…

#146

Bluecloud, didn’t you say you were recovered with Avodart?

#147

What a world we live in. I can buy heroin on the street anywhere but xyrem is almost impossible to get

#148

A guy that I know personally has recently claimed to have improved substantially after taking some GHB (he is mainly suffering of cognitive problems). It’s too early to say though, if the effect will last or what the long term outcome will be. Nevertheless, I find this news very interesting.

My impression is, that just about everyone who has tried GHB/Xyrem has had an improvement. On the other hand, it seems that not many guys have tried it so far, so it is hard to get a clear picture regarding the subject. I would like your help to jog our collective memory of this forum and to verify this impression of mine.

Is the success rate of GHB/Xyrem really as good as it appears to me or am I seeing this wrong? Can anyone recall a member who has tried GHB/Xyrem and did not have an improvement?

Thanks for your help.

#149

@ Boston332 Regarding talking to a female about these problems, for me PFS meant I had no emotion, so it did not make a difference who i was telling it to. However, I will add that i didn’t verbally communicate everything to her. She actually asked me to put it down in a letter, which I did in great detail. I think she felt more comfortable with this approach, rather than have me tell her about all my symptoms. Also, we have to remember that Dr’s don’t have too much time to see patients, and us PFS guys have so many symptoms it sounds like we’re hypocondriacts and must drone on a bit to them, albeit very serious for us. Putting things in a letter gives them the time to read it, potentially mull it over, also means it’s on file for other Dr’s to see, consider etc. Each time I went to meet her I brought a new letter of update and we started our meeting with her reading my letter; my current condition etc. Then i’d propose course of action and she would advise good idea/bad idea etc., but in every instance she felt comfortable with my approach. She believed me 100% and also knew I was an intelligent guy due to the way i expressed myself in my letters. I’m not sure if this will work for you, but try it out. I also had some speech problems, fumlbing for words etc. + very dry mouth, so the letter meant I didn’t have to say too much.

@ Bluecloud Please calm down. All I am saying is if you don’t try, you don’t get. For the record, I actually don’t think I need to get Xyrem anymore, but I am going to pursue the avenue anyway because my sleep still isn’t 100%.

@ Awor [Chi bows] I am glad to see you taking an interest in this area. Research aside, I think we could be on to something here that has never really been given the attention it deserves. There is definitely a GABA element to PFS - The muscle twitches, the poor sleep, the inability to relax and feel emotion, the GABA dependent pelvic floor dysfunction (connected to prostate). In addition, many of us have reported feeling much better AFTER drinking alot of alcohol. I read quite a bit about how alcohol is a GABAA receptor upregulator in the days AFTER use. I actually had a full blown recovery after a night of heavy drinking once.

#150

@ Awor, sorry I am very lazy, but I think I read of one guy on the forum who actually got some sides from Xyrem and decided to stop the medication. He said it didn’t help him either. I’m sure one of the minions can dig it out for you. That said, the one story and report I think is of most interest is Ithappens. Reason being is he was pretty active on the forum as far as I can tell and seemed to have a pretty bad situation at 1 year off the drug. Sorting his sleep + GABA deficiency problem through Xyrem saw him through a complete U-turn and as far as we are concerend the guy is fully recovered, well atleast it seems that way from his final posts. I believe Paulwalters2006 goes into the potential mechanisms a bit better that Ithappens.

Basically what we need is some GHB for more of us to experiment. Is this something one of your labs could prepare for us if you put a case forward and attempted to explain the mechanisms behind it (whatever they are)? I know it’s a long shot, but it might be worth starting something up on the side of the research.

#151

if you could try to look this up, it would be a huge help. i want to see what happened with this guy. i tried researching this through the forum before… didn’t find anything about this. i’ll try to look again.

#152

Oneday used GHB after getting it via a sleep study but reported no benefits, although he did only use it a few days.
19 also used it and said it didn’t help him.

Popo said GHB helped him with libido and facial hair growth but never seems to get mentioned.
Also, this guy ghbeameup who took fin: groups.google.com/group/alt.baldspot/browse_thread/thread/d241e2f1e665a159/b039e78d127d5811?hl=en&q=#b039e78d127d5811

To my knowledge no one who got severe sexual problems like total libido loss, bad ED and structural changes has improved from it.

#153

I wouldn’t speculate too much about the mechanism of action if I were you. It is likely that an entirely different property of GHB is causing the positive effect that we are seeing, one that ties in very well with the etiology that we are investigating.