Gene Therapy to Delay Reproductive Senescence

Gene Therapy to Delay Reproductive Senescence: Affecting brain inflammation may be an upstream key.

By Josh Conway

November 7, 2022

A team of Spanish researchers publishing in Aging have reported that they can delay reproductive senescence in female rats by stimulating the production of insulin growth factor 1 (IGF-1) through gene therapy.

IGF1 gene therapy in middle-aged female rats delays reproductive senescence through its effects on hypothalamic GnRH and kisspeptin neurons

Franco Juan Cruz Dolcetti , Eugenia Falomir-Lockhart , Francisco Acuña , Macarena Lorena Herrera , Sofia Cervellini, Claudio Gustavo Barbeito, Daniela Grassi , Maria-Angeles Arevalo, María José Bellini

Received: June 3, 2022
Accepted: October 21, 2022
Published: November 1, 2022