https://www.nature.com/articles/s41586-022-04668-3
Hearing loss caused by aging, noise, and some cancer therapy medications and antibiotics has been irreversible because scientists have not been able to reprogram existing cells to develop into the outer and inner ear sensory cells — essential for hearing — once they die.
But Northwestern Medicine scientists have discovered a single master gene that programs ear hair cells into either outer or inner ones, overcoming a major hurdle that had previously prevented the development of these cells to restore hearing, according to new research published May 4, 2022 in the journal Nature.
“Our finding gives us the first clear cell switch to make one type versus the other,” said lead study author Jaime García-Añoveros, PhD, professor of Anesthesiology and Neuroscience and in the Ken and Ruth Davee Department of Neurology. “It will provide a previously unavailable tool to make an inner or outer hair cell. We have overcome a major hurdle.”