Gaba and Neuroactive Steroids

[golf]

ncbi.nlm.nih.gov/pmc/articles/PMC2435342/

This has tons of information on GABA and the role of neurosteroids and relation to androgens… great deal of information.

increase in THP and THDOC synthesis induced by γ-hydroxybutyric acid (GHB), a metabolite of GABA [17,219]. The neuroactive steroids so formed, in turn, acting as amplifiers of the GABA neurotransmission play a role in the GABA-A mediated action of GHB

Finally, it has been reported that neuroactive steroids not only interact with the GABA receptors, but also may regulate GAD expression, thus, the synthesis of GABA [86]. For instance, P regulates GAD expression in the rat brain during a physiological status, like the surge of gonadotropin hormone releasing hormone (GnRH)