Free hormones VS bound hormones - Siliva tests, need ur help

General Discussion
#1

Hello.

I have been doing lots of tests and trials.

I have found that I have high siliva progesterone and estradiol along with low T and DHT.

In blood tests free T is also low but progesterone and estradiol are at good levels (mid range)

The siliva tests clearly explain my symptoms. The question is why the discrepancy?

I tested 17-hydroxy-progesterone in blood and found it to be 2.5 times the range. This to me could explain the high free progesterone levels and low free T. Of course this would keep LH and FSH relatively low despite low free T levels.

I posted a while back that pregnant guinie pigs become totally resistant to testosterone shots. And in fact testosterone can decrease their cortisol when it will usually increase it when they are not pregnant. This explains my experience with TRT. I only felt some short term benefits on trt and then felt worse.

Could some more people here test your free hormones : You may find they explain what you are experiencing.

If you are in the US you can do this here - diagnostechs.com/Pages/Intro.aspx or ZRT labs, I am sure there are many other places.

Please test T, DHT, e1, e2 ,e3, progesterone, 17-hydroxyprogesterone, androstenedione, dhea and cortisol.

It cost me 200 bucks to do this and was worth every sent. Going to the doctor often costs more and ends up being no benefit.

You do not need a doctor to order these tests for you.

Please do these tests and report back. Do not delay we need to do all we can to shed more light on this condition.

Thanks

#2

So what specifically causes a pregnant guiniea pig to be totally resistant to testosterone? Obviously I would think an increase in some hormone, and not like an androgen insensitivity situation

#3

Progesterone.

vincent do you have any theory on the discrepancy between saliva and blood hormones? is the former simply unbound hormones i.e. not carried by SHBG?

#4

All I know is that 5 day use of progesterone no doubt 100% affected me

#5

if you would please, go on …

#6

Well I read an article stating that 17 hydroxy progesterone levels are extremely high within some organs (ovaries, I think). It was stated that the hydroxy progesterone binded with the carrier proteins which left progesterone to float free in high levels. That could perhaps explain my very high levels of siliva progesterone despite low blood levels. As for the e2, I am not sure. My blood free T and siliva T do match.

Here is the study regarding the gunnie pig. hawaii.edu/PCSS/biblio/artic … inity.html basically they suggest that the temporary testosterone resistance that is seen during pregnancy is progestin dependent.

If you are doing blood tests. These only tell half the story. We test free T because we want to know the quantity of hormone which is free to act on the cell. We should also be doing this with all other hormones. Simply knowing blood levels is not enough and does not give us a full picture. All of us should seek to do a full siliva hormonal profile asap. For me they very much paint the picture of my situation.

#7

So progestins? That’s interesting bc that’s what thought to atribute to women who crash on Mirena IUD birth control, they have strikingly similar complaints

#8

Ok, when I took the progesterone I was actually doing quite well and definitely improving. I 100% crashed back down with it, my face was bright red, my sex drive was non existant, and skin really really got dry. Now my theory is that progesterone stimulates the estrogen receptors and I have a feeling that’s what happened. I’m going to see how I rebound from this, in the past every major downswing was followed by an incredibly upswing with sustained improvements.

I feel like when my face is really red, there is an area that gets even darker right above my eyebrow ridge, it’s like heat emanating from the prefrontal cortex lobe. Anyone else get this? Suffice it to say, when I took the progesterone, it maybe my face super bright red

#9

Well my scrotum has been red since I crashed on fin. When I took progesterone it also went bright red. I do not know if too much can be learnt by that in itself. Some say red rashes are common with high e2 levels. There probably could be many reasons.

#10

So is anyone going to do this?