Moonman, what about most of the guys with PFS who do respond to test and Masteron? The forum is littered with posts of guys who responded to Masteron and then crashed etc… It seems very rare for a guy with PFS to be completely non responsive to androgens, MCI for example is on testosterone cream which is very very very weak, and he is having minor improvements on it, enough to make him consider switching to injectable.
We have to be careful about these declarations, Awor’s posts have caused a lot of unnecessary suffering by guys who believed they were non responsive to androgens. It seems that there are some guys with PFS who are non responsive to hormones, and most have varying degrees of responsiveness that improve with time. Moonman, it has taken me 9 months to get to where I am, 6 weeks on test was nothing in the span of my experiences. I am not putting yours down, you have had this for 10 years, I want you to find a way out of this, I think you are a very intelligent and great guy, and I hope we find a way to fix this for everyone.
However, Awor’s posts have really caused a lot of unnecessary suffering, when I met MCI, he was convinced he was non responsive to testosterone. That is simply not the case, in my case, the more I increase 5AR, the more I reduce test to DHT, the more I respond. It’s possible that we are dealing with 2 different syndromes here as well, one where a there is complete non response to androgens, and another where there are varying levels of response that improve over time. Moonman, there were times you did respond to tribulus spontaneously for no reason, no?
The more I respond to testosterone, the more sebum production is on my skin, this only occurs from 5AR type 1, when estrogen rises, my oily skin shuts down, and I get bloated, and an array of effects occur, this is reversible with an aI. Also, Masteron shuts off my 5AR enzymes, my oily skin, acne, all shuts off with Masteron. I believe taking finasteride caused our enzymes to be destroyed, then re-created mutated, this created a 5ar antibody, now our immune system is attacking our 5AR enzymes. It is possible in your case that you have A LOT of mutated 5AR enzymes.
Why would you spontaneously respond to tribulus? Is it possible that those couple times, your immune system was somehow low, and you responded? The only time Mew ever has reversal of his PFS symptoms was one week he was very sick with a virus. My symptoms of PFS improve when I am sleep deprived, to my surprise a few others posted that their symptoms improve when they are sleep deprived. If it is not related to the 5AR enzyme, then why does oily skin stop with PFS? Oily skin is produced only by the 5AR enzymes, why does hair loss stop? Hair loss is caused by the 5AR enzymes, why does body oder stop? This is also caused by the 5AR enzymes. Why do guys have visual and neurological problems, and the 5AR type 3 enzyme is responsible for visual and neurological function, muscles, libido, all are from the 5AR 1, 2 enzymes.
Is this were the androgen receptor gene, then why have all of us lost the actions of the 5AR enzymes? Why is it when guys improve their improvements coincide with actions of the 5AR enzyme i.e. oily skin, hair loss etc? Why would Masteron shut down my oily skin and clear up my acne from testosterone? Masteron normally increases the expression of 5AR HIGHLY in normal men, is it possible that in us it is inducing an immune response? The voices of the non responsive are much louder than the voices of the responsive, and for good reason, and those voices of the non responsive echo for years on this forum, following them with suicides from guys who believe their situation is hopeless.
That guy Dan who committed suicide, did he read Awor’s posts? Did he ever try going on testosterone, or was he afraid to? I am not discounting your theories Moonman, for the sake of us all, please pursue them, but your experiences do not reflect mine. To say that you are 99% sure this has nothing to do with the 5AR enzyme is a big leap, when I am 99.9% sure it does at least in my case have everything to do with the 5AR enzyme. How do you explain recoveries from PFS? Ihatepropecia recovered 100% after having surgery, being on high doses of immunosuppressive drugs, we are in regular communication. He was once as bad as you, now he is 100% better, and response perfectly to testosterone.
What if your 5AR enzymes are mostly mutated and all being attacked by your immune system? What if that just makes you think you are non responsive to androgens? You have no explanation for why you spontaneously responded to tribulus 2 times? I do, you said you made gains from hydrocortisone, gains in brain fog, but not sexual gains. Others have made sexual gains with Hydrocortisone and dexamethasone. I have found that people I talk to with PFS have autoimmune disorders in their families, I do, MCI does,
What was it that Awor said? Testosterone was just as bad as taking more finasteride? It is the only thing keeping my muscles, libido, me alive, though I am not consistently responding to it correctly, without it I would be really really bad off. I tried lowering my test and stopping it a couple times while I had PFS, and it was HELL, perhaps you should rethink this is all I am saying…
Follow through with your tests, it will be interesting to see the results, but there are drug induced autoimmune disorders, Lupus for example. I hear another endo came up with the same theory as mine, that this could be a drug induced autoimmune disorder. For those of us who do respond, it certainly does seem like we are fighting something that is adapting, something like an immune system.
Something to think about…
Moonman, are you and I dealing with the same syndrome? Please don’t misread my post, it is not an attack, it is a response, these words will remain here for who knows how long, they can cause untold damage, so they must be balanced. The one thing we can all be confident about, is that we have people like Moonman, and me, Eden, and Mew to fight this on every angle, with all these minds and wills, answers will surely come soon enough.
