Finasteride Study on Rats

[BadLuck]

I found this fairly extensive study of finasteride in Rats that I thought I’d pass along. Unfortunately I’m not smart enough to understand alot of the technical details, so was hoping someone could take a look at it and see what they thought. Here is the link:

mcponline.org/cgi/content/fu … type=HWFIG

From what I can understand this stuff affects tons of stuff in our endocrine system. Here is a quote:

“Under our experimental conditions, finasteride induced ventral prostate weight loss and atrophy and modified the expression level of 37 proteins as revealed by two-dimensional gel electrophoresis (2D-gel) pattern analyses.”

Another quote:
"The prominent feature of this study is the demonstration of finasteride dose-dependent up-regulation of a protein similar to L-amino-acid oxidase 1 (Lao1). An up-regulation of this protein was also observed with the antiandrogen flutamide. Lao1 expression occurred as early as 48 h after antiandrogen administration and persisted throughout the treatment duration. Immunohistochemistry showed that this protein was only detectable in epithelial cells and secretory vesicles. Altogether these data point to a potential use of Lao1 to reveal antiandrogen-induced prostate injury. "

Apparently this protein Lao1 has antiandrogen properties in the prostate. Any of you biologists familiar with this protien and it’s effects on us?

[Mew]

This study already posted:

propeciahelp.com/forum/viewt … 0175#10175

[BadLuck]

Sorry about that Mew. It was news to me. You can delete my post if you want.