@Cedric In case this message reaches you, I would deeply appreciate if you tells us if you have improved on Corticosteroids or not and how you are doing these days. Thanks and take care!
Hi Michael,
Unfortunately, since I stopped finasteride, I am accompanied by asthenia which can be profound (with weakness, numbness and epigastric pressure) or light which allows me to carry out daily activities. With the immunologist I found out that all my lymphocytes are below range, but since the cd4/cd8 ratio is preserved, none are activated to get to the bottom of it. The only lymphocytes that are in range are NK cells which are also beyond the maximum range. Unfortunately I only had problems with cortisone, it often accentuated my tiredness. I initially had a partial benefit by doing a few vaccines in sequence to stimulate the cells. Currently, 10 years have passed since it was discontinued but I still donât have a valid explanation for this asthenia. I hope you are better than me physically. let me know, bye
@Cedric Thanks a ton for your response!
Have you been able to treat your EBV somehow?
For me itâs been getting worse year by year, COVID19 worsened me in a big way.
I have mostly neurological, sexual and fatigue symptoms - however no GI issues - although the latter is very common with PFS.
Are you aware of this: https://www.youtube.com/watch?v=mQAnwC6dTkE ?
(Donât take me as endorsing it, but I found the angle interesting).
Wish you all the best!
Ciao Michael,
Ho usato un anti-virale per qualche settimana, ma è stato un tentativo perchĂŠ in realtĂ non era certa la sua presenza in quel periodo, anche se dagli anti-geni avevo sicuramente contratto la mononucleosi. Ad ogni modo per fare piazza pulita presi lâantivirale.
La tipizzazione mostra sempre e comunque cd3, cd4 e cd8 bassi, ma con un rapporto conservato. NK alte quindi difficile si tratti di cfs. Presumibilmente la finasteride a immunosoppresso la quota di linfociti, e il mio organismo attualmente funziona a giri ridotti. Comunque non ho la controprova purtroppo perchĂŠ prima dellâuso di finasteride non avevo mai testato i miei linfociti che possono essere stati sempre in sottonumero ma in rapporto utile. Guarisco in fretta dalle infezioni quindi mi fa pensare a questâultima ipotesi. Il mio problema attuale è solo lâastenia e la lenta risposta allo sforzo ed al recupero. Sessualmente sono ok, a parte lo stare male fisicamente dopo lâeiaculazione, ma la libido è ok. Infatti prenderò un appuntamento con un andrologo per capire come contrastare questo calo drastico di chimica ormonale/neurosteroidea ecc. durante lâeiaculazione. Per quanto riguarda lâastenia ho anche certificato questo sintomo con il test cardiopolmonare che ha valori nettamente inferiori rispetto a quello che ci si aspetta da uno della mia etĂ .
@Cedric I also feel unwell after orgasm (similar to POIS but not as dramatically, see: e.g. https://poisdata.org/ / https://poiscenter.com).
Our symtpoms seem very similar - I also suffer from asthenia and a slow response to exertion and recovery.
Iâm still discerning if this is from COVID19 (i.e. if I have Long Covid) or if it has been âjustâ PFS worsening over time.
Have you checked your hormones?
Hi Michael, yes, tell me a little about your symptoms and what youâve been testing. As far as Iâm concerned, yes, Iâve tested all the hormones and theyâre all normal at a plasma level. I am trying to eliminate all possible stress (both mental and physical) which exacerbates asthenia and as I have found in the past improves both physical and mental resistance. I didnât think I had such a low resistance to stress but probably finasteride has developed some flaws at a metabolic level. I have tried taking various supplements that improve metabolic function and therefore energy but almost all of them give me a rebound of weakness/asthenia. The only one that initially gave me benefit even for many months was acetyl-carnitine taken with the drug nicetyl. Then I stopped because I felt it was âacceleratingâ me a little too much and then I know it needs to be stopped. Update me! HI!